dale, was the fame as now adopted; but by fome vague pretenfions of the former, the public opinion ran very generally in their favour, till Baron Dindale pub1.thed his account of the Suttonian method. (No. 14.) Mr. CLINE, Member of the Royal College of Surgeons, and Surgeon to St. Thomas's Hospital, ftated, That in July, 1798, he received fome vaccine matter from Dr. Jenner, with which he inoculated a boy who had not had the fmallpox; when he had gone through the #ages of vaccine-inoculation, he tried to infect him with the fmall-pox, by inoculation, but in vain; this circumftance, together with the communications he received from Dr. Jenner, produced the ftrongest conviction in his mind of the great utility of this practice, and he therefore recommended it strongly to all his friends, among whom was Sir Walter Farquhar, and he perfectly recollects the converfation relative to the emolument Dr. Jenner might derive from the practice of vaccine-inoculation; but Dr. Jen. net at that time declined fettling in London. Mr. Cline looks upon it as the greateft difcovery ever made in the pracfice of phyfic, for the prefervation of the human race, as the fmall pox had been the most deftructive of all diseases. Mr. Cline was confulted upon the cafe of a child of Mr. Austin at Clapton, with whom it was faid the cow-pox inoculation had failed; but from particular enquiries of the parents and nurfe, he was perfectly convinced the child had never received the vaccine-difeafe; and this evidence Mr. Taylor, the Surgeon, who inoculated it, confirmed. He thinks that experience has fufficiently demonftrated that perfons inoculated with the cow-pox, are incapable of receiving the fmall-pox, and he be lieves that is the infances where the fmallpox has been caught, and the patient has, before the coming out of the difeafe, been inoculated with the cow-pox, it mitigates the virulence of the small-pox. The vaccine-disease is not contagious, nor does it create any blemish on the human frame; nor does it excite fcrofula, or any other difeafe, which is fornetimes the cafe with the inoculated fmall-pox. In November, 1800, he performed the operation for the ftone on William Rench, a child in Ifaac's Ward of St. Thomas's Hofpital. In a few days after, hearing that this boy was in great danger of catching the fmall-pox, he directed that he fhould be inoculated with the cow-pock matter, which took effect, and proceeded in the ufual manner: but in thirteen days after this inoculation, a few eruptions appeared that feemed to be variolous. Admitting thele eruptions were the true fmall-pox, the time of their appearance fhows the infection had been received before the child was inoculated with cowpox matter; for the natural imall-pox frequently does not appear until fixteen or eighteen days after the patient has been expofed to infection. A fecond cale was in November 1801, the child of Mary Solloway, in Mary's Ward of the fame Hospital: this child was known to have been expofed to the infection of the fmall-pox, and therefore the mother permitted it to be inoculated with cow pock matter; but in four days after, the fmall-pox appeared, and the diftate, was very levere; however, the child recovered. A third cafe was a patient of Dr. Lif. ter's, whole mother bad the fmall-pox.In fix days after the complaint had appeared in the mother, the child was inoculated with cow-pock matter, and the complaint from this inoculation proceeded as uiual; but in about fifteen days a tew eruptions appeared that were of a doubtful nature. From the most minute inquiry, these are all the cafes which have occurred in S. Thomas's Hofpital, where variolous erup tions have fucceeded the vaccine-inocula tion, and in each of which there can be no doubt that the patients were expoled to the infection of Imall-pox previous to their be ing inoculated. (No. 33 ) Mr.DAVID TAYLOR, Surgeon of Wooton under-Edge, Gloucestershire, spoke to cafes which had been brought before the Committee,as difproving the efficacy of cow. pox in preventing fmall-pox; the one a child of Mr. Auftin of Clapton, the other of a woman at Old Sudbury. With regard to the firit, he had inoculated the child with vaccine-matter himfelf, but did not fee the progrefs of the disorder, nor was the child attended by any medical perfon; but from the account given by thofe who were with the child, he was apprehensive at the time that the vaccine-diieafe had not taken effect, and ftrongly recommended that the fhould be inoculated for fmail-pox, which the afterwards caught in the natural way. He stated, that a full and minute invettigation of the fecond cafe had been made by five or fix perfons, who were unanimous in their opinion that the woman at Old Sudbury had never had the cow.pex. His own practice in vaccine inoculation has been confiderable, and he has inocu. lated about 2000 perfons without a fingle failure; nor has he met with any ulcerations, humours, or difeafes following it, fuppofed fuppofed to be excited by it. He has inoculated a large proportion of his patients with variolous-matter afterwards, without any difcafe being produced. He further stated, that he was acquainted with the extent of D. Jenner's medical practice before he left Gloucefterth re, where he was fituated in a very populous neighbourhod, without any pract.fing phyfician within 16 miles; well fupported, and of course in the moit confiderable practice; and he thought that in confequence of his quitting bis ituation in the country, and coming to town, he had leffened his income moft confiderably, as two phyficians had fucceeded to the fituation which Dr. Jenner had left, both of whom are in confiderable practice; and of course Dr. Jenner's former fituation cannot be re-attainable. (No. 40) Mr. JORDAN, Member of the Royal College of Surgeons, two or three years ago inoculated between one and two hundred with vaccine matter; fome matter was received by him from the Apothecary of the Inoculation Hospital (over which Dr. Woodville prefides) for vaccine, which proved to be variolous; the patients, not being prepared for it, were very ill, but recovered; he has avoided thefe miftakes fince, by taking the matter himfelf from the patient; and has learnt by Dr. Jenner's publication how to diftinguish and select the proper time for taking it, fince which no mistake of the kind above-mentioned has occurred. He is of opinion that errors of that kind brought vaccine-inoculation for a time into difrepute. (No. 25.) Mr. GARDNER has known Dr. Jenner more than twenty two years, and been in the conftant practice of hearing his medical opinions and difcoveries. It was in the month of May, 1780, that Dr. Jenner first informed him of the particular nature of the cow-pox as a fure preventive from finall-pox, and the theory he had framed on the subject; declaring his full and perfect confidence that it might be continued in perpetuity of inoculation from one human being to another, in the fame way with the fmall-pox, and in time fuperfede that difeafe. (No. 26.) Dr. THORNTON, Phylician to the Maryle-Bonne Difpenfary, ftated the cafe of two children belonging to Lord Somerville's coachman, whom he inoculated three years ago, with what he fuppofed to be true cow pox matter; the matter from which the inoculation was performed at that early period of vaccine-inoculation, was taken indifcriminately, as long as there appeared a puftule from whence matter could be pro. cured, he being unacquainted at that time, that the cow-pox inoculation ceased to produce the disease after a certain period, which was known to Dr. Jenner, and publifhed by him, and forms one of the important difcoveries refpecting the new practice; he was fome time afterwards informed that these two children had the small-pox, and upon examining their arms, there were found no fears, which is a criterion that these children had not had the true cow-pox, and he was confirmed in this belief by the mother of the children declaring that the puftules had advanced more rapidly than in the true cow-pox; this cafe appears to him important, as exhibiting a proof that all other cafes adduced against the general principle of fecurity from vaccine inoculation, muft arife from want of acquaintance of the inoculator with the period when to take the matter; which difficulty he deems to be now completely done away, by Dr. Jenner having chicidated a subject before involved in much obfcurity. He further ftates, that matter taken from a puftule, which was a week old, never failed to produce the true cow-pox ; but in the aforementioned instances of the two children, he has great reason to believe it was taken the fourteenth day, or later: he ftates another source of spurious cafes in the lancet being corroded with the cowpox matter, on which it is placed; he inoculated a week before fome patients from the fame matter with which he inoculated the afore-mentioned children, who went through the disease in a regular way; one patient in particular has been, during thefe laft three years, inoculated with (mall pox matter at least twelve different times; he has even flept with a perfon who died of the natural small-pox, and has been otherways expofed, but could not take the infection: he fays, when he was in the north, at Lord Lonsdale's, he inoculated upwards of one thoufnd perfons, and completely fatisfied himself, and all the medical practitioners in that part of England, that the cow-pox was a mild disease, hardly deferving that appellation; not contagious, never disfiguring the perfon, never producing blindnets, never fatal, nor exciting other difeafes; equally fafe, whether during the period of pregnancy, or the earlieft infancy, or extreme old age. (No. 20.) Earl BERKELEY ftated, That his youngeft fon was inoculated with the cowpox, by Dr. Jenner, at fix months old, and went regularly through its course; about a year after a maid-fervant in the family caught the small-pox in the natu ral inoculated with fmall-pox, a flight local inflammation fhewed itself, which difap ral way, and was attended by Mr. Rohert Pope, furgeon, from Staines, who pronounced the girl to be in a very dan-peared in four or five days; fome of these gerous fituation; having in the houfe at perfons were put to the teft of the fmallthat time three perfons who had been pox, after a period of a year. The perinoculated with the cow-pox, the child fect puftule is always to be diftinguished above-mentioned, a maid fervant, and a from the imperfect or fpurious, by those little girl, and being defirous of proving who have paid a proper attention to the the efficacy of vaccine inoculation, he fent practice of vaccine-inoculation. He befor Dr. Jenner and permitted him to lieves that vaccine inoculation will freinoculate the child and one of the girls quently fuperfede the infection of the with variolous matter, taken from the small pox, when the patient has been exmaid-fervant; the fmall-pox took no posed to a variolated atmosphere previous manner of effect on either of them (the to the inoculation, in confirmation of girl had been inoculated with vaccine which he related a cafe under his own matter four years before) the other girl immediate obfervation. A boy, infected that was not inoculated attended on the with the natural small-pox, came home to maid fervant the whole time until her his father's cottage; four days after the death, and refifted the infection.-The eruption had appeared upon this boy, the effluvia in that part of the house was fo family (none of whom had ever had the offenfive, that all the fervants were fmall-pox) confifting of the father, moobliged to be removed to another part of ther, and five children, were inoculated the house. Lori Berkeley further ftated, with vaccine virus; on the arm of the That there is an old fervant now in his mother it failed to produce the leaft effect, family, feventy-two years of age, who and fhe had the fmall pox; but the fix had the cow-pox, from milking cows, others had the cow-pox in the ufual mild when a boy of fifteen, who has never way, and were not affected with the smallbeen in the leaft cautious in guarding pox, although they were in the fame against the small-pox, but has expofed room, and the children flept in the fame himself repeatedly, without being fenfible bed with their brother, who was confined of its effects; and Lord Berkeley once faw to it with the natural small-pox, and fubhim, himself, fitting next a boy who had fequently they flept with their mother. the fmall-pox vifibly out upon him. (No.6.) He is of opinion, that if the practice of Robert Pope, furgeon, at Staines, at- vaccine-inoculation is univerfally adopted, tended the maid-servant from whom Earl it will in a fhort time annihilate the finallBerkeley's fon and the girl were inocu- pox. He has known many inftances of Jated with variolous matter; he depofed the infection not taking in the early part to the virulence of the disease, and to her of his practice, owing to his uúng vacdeath in confequence. His opinion was cine-virus taken at too advanced a stage not favourable to vaccine-inoculation on of the disease; but fince he has made it a the first publication of it; but he is fince rule never to inoculate with matter after pretty well convinced, that if properly the eighth or ninth day of the disease, he conducted, it is a preventive of fmall- has feldom met with a failure; he inocupox, and he has practifed it himself with lated two hundred and thirty-eight indifuccefs. (No. 7.) viduals on the fame day, with recent fluidvirus, taken on the eighth day of the difeafe, and every one of them had the cow-pox in the most perfect manner. The progrefs of the cow-pox is in general uniform; he has seen a few exceptions, one or two cafes have occurred when the progrefs of the disease has been retarded for at least a fortnight before there were any vifible appearances of the inoculation having fucceeded; the courfe of the fpurious ditorder is univerfally quicker than the perfect, fo as to form a certain criterion between the forts in every cafe which has come under his obfervation; when the puftule affumes the genuine character, the patient may be confidered as fafe from any future attack of the fmall-pox, although there has been no The Rev. G. C. Jenner is converfant in the practice of the vaccine-inoculation, and has inoculated three thousand perfons, without meeting with one unfavourable cafe, although he has inoculated perfons from the earlieft infancy to eighty years of age, and under thofe circumstances in which it would not be prudent or indeed safe to inoculate with variolous virus, fuch as children at the time of dentition, and women in every stage of pregnancy, from the first month to the last week. Upwards of two hundred of his patients have fince been inoculated with active imall-pox matter, and at least an equal number expofed to contagious effluvia, but in no one infance was the fmall-pox produced. On the arms of fome of thofe MONTHLY MAG. No. 90. apparent apparent (No. 8.) conftitutional indifpofition. facts, was delivered in, figned by Sir Alexander Ball, governor of Malta. In Sicily, the finall-pox had been, if poffible, ftill more fatal than in Malta; for the computation of deaths, occafioned by it in the year preceding his arrival, exceeded eight thousand in the city of Palermo alone: the introduction of the cow. pox was therefore received with enthufiafm, and an hofpital, imilar to that at Malta, was immediately established by his Sicilian Majefty; and although the smallpox, foon after his arrival in the city, again appeared, it was immediately ftopped by vaccine inoculation, which was alfo extended through the whole island. The benefits received at Palermo from the cow-pox excited a great wish for its practice in Naples, where the fmall-pox has always been confidered as very fatal. An hofpital was also there established by his Majefty, and the practice of vaccineinoculation was speedily adopted throughout the whole kingdom; His Majesty having commanded that children to be inoculated, attended by furgeons to be inftructed in the practice, fhould be fent from each province to the hospital at Naples, to carry both the knowledge of the disease, and the practice of it into their respective provinces. On his leaving Naples, the witnefs received very honourable teftimonials from His Sicilian Majefty, which were produced. He alfo extended this practice to other parts of Europe, to Rome, Leghorn, and Genoa, and in every inflance, where tried, he found it refift the infection of fmall-pox. He never heard that any fuch mode of inoculation had been practifed or known in thofe countries before; and as an example of the disbelief entertained by the medical men of Naples, he related a trial which they inftituted foon after his arrival there, and without his knowledge, at the Foundling Hofpital; where they first inoculated with the cow-pox a confiderable number of children; and after they had paffed through the disease, exposed them to all poffible modes of infection of the fmali-pox, both by inoculation, and by making them fleep in the bed with people infected with the fmall-pox. This trial, which had excited the attention of the whole city, completely established the reputation of the cow-pox; and they ap pointed a deputation to him, publicly to exprefs their conviction of its efficacy. He believes the number inoculated under his direction was upwards of ten thousand; many of them were fubjected to every poffible means of variolous infection, which all of them refifted. He never did obferve the Dr. JOSEPH MARSHALL, Phyfician Extraordinary to the King of Naples, first began to inoculate in the fummer of 1799, in Gloucestershire, having received inftructions on this fubject from Dr. Jenner. In July, 1800, recommended by Dr. John Walker, who affited him in fome of these inoculations, he commenced this practice on board his Majefty's fhip the Endymion, eleven of whofe crew were inoculated, and went through the vaccine difeafe without any remiffion of their ordinary duty, or any deprivation of their ufual allowance of wine or provifions. He alfo inoculated fuch foldiers of the garrifon of Gibraltar, as had not had the finallpox; the plague, at this time, prevented the garrifon from receiving the ufual fupplies of fresh provifions from Barbary; and Spain was fhut against them by the war; their food in confequence was principally falt provifions fent from England, and they generally indulged in drinking new wine; this diet, added to the exceffes which foldiers ufually commit, put the cow pox to a fevere trial, especially when it is further confidered that they, whilft under inoculation, performed their ordinary regimental duties; and fo far was the cow-pox from preventing their doing this, that not a fingle cafe occurred where any application was requifite to the inoculated part, though the heat of the atmosphere was frequently upwards of ninety degrees; in corroboration of which the furgeon-major's certificate was produced. At Minorca the fame fuccefs at tended the inoculation, where it was alfo generally introduced amongst the inhabitants; and their medical men were inftructed in the practice; fuch feamen alfo on board of the British fleet, under the command of Admiral Lord Keith, as had not had the fmall-pox, were inoculated with the cow-pox. At Malta, its practice was alfo generally introduced both among the troops and inhabitants; and an hofpital, called the Jennerian Inftitution, was established by the governor, for the inoculation of the poor. In this ifland the ravages of the fmall-pox had always been dreadful; and fome of the men of war then in the harbour, had the fmallpox on board, and had buried feveral men; this apprehenfion was alfo entertained by the Admiral and General Sir Ralph Abercrombie, who each iffued general orders for the inoculation of fuch feamen and foldiers, under their respective commands, as had not had the fmallpox. A certificate, confirming the above vaccine vaccine inoculation to introduce or excite any other difeafe; on the contrary, children in a weak state of health have immediately, after paffing through the vaccine inoculation, begun to thrive and became vigorous. He is of opinion, that the fpurious or imperfect fort is eafily diftinguishable from the perfect difeafe, and that perfons who have once feen the true cow pox puftule can never be mistaken. (No.9.) Mr. JOHN GRIFFITHS, Surgeon to the Queen's Household, and to St. George's Hospital, has inoculated upwards of fif. teen hundred persons with vaccine-matter, not one of whom has had any untoward fymptom; among them three of his own chiuren, at various periods, within three years. (No. 10.) Dr. SKEY, Phyfician to the Worcester Infirmary, ftated, That in the spring of laft year, the fmall pox being generally and fatally epidemic in the city of Worcefter, he seized the opportunity of inoculating a number of children with the cowpox; that in the district where he inocuculated the greatest number, the small pox contagion ceafed to exert its influence, and the number of victims gradually diminifhed; that in every cafe which he witneffed, the inoculated cow-pox was incomparably less severe than the natural fmall-pox that none of thofe patients whom he inoculated with vaccine-matter, received the small-pox afterwards, although they were conftantly expofed to the fmall pox contagion, and altho' cafes of the two difeafes not unfrequently occurred under the fame roof, and at the faine time; that he had never yet known a cafe in which any confiderable degree of hazard was in curred by the vaccine-disease, and that he had not met with a fingle inftance in which, after a second or third inoculation, he did not fucceed in producing the vaccine-difcafe. (No. 14.) Dr.CROFT has paid particular attention to vaccine inoculation ever fince its first introduction; from that time his own children have been inoculated with it, and he has uniformly recommended it to his patients; he has even recommended infants to be inoculated at the end of the month, but he never dared to recommend the inoculation of the small-pox earlier than at two years of age, except under very particular circumstances. Upon being defired to relate what he knew concerning the inoculation of a child of Sir George Dallas, he stated, that he recollected a child of Sir George Dallas's being inoculated with the vaccine-difeafe by Dr. Jenner; he believed, in five days from the time it was inoculated, it broke out with the fmall pox; it went through the difeafe rather favourably; he was not called in to the child till about the third or fourth day of the eruption of the fmall-pox, when the arm inoculated appeared in the ftate one thould naturally expect to find it from the fifth to the feventh day. He imagined that the inoculation of this child with the vaccine-matter might have fome effect in abating the violence of the natural fmall-pox, the eruption not being equal to what might have been expected from the violence of the firft attack of fmall-pox fever. Sir George Dallas has fince had an infant of one month old inoculated with the vaccine-disease. He had feen children, whose arms had been confiderably inflamed from being inoculated with matter taken from under the vaccinefcab as late as the fourteenth day, but does not know why this fhould be called a fpurious fort of cow-pox, as they had none of the characters of vaccine-difeafe. He is of opinion, that if the vaccine-inoculation were generally introduced, it would be productive of greater bleffings on mankind than any difcovery that was ever made in medicine, and it would ultimately cause the small-pox only to be remembered by name. (No. 15.) Mr. JAMES SIMPSON, Surgeon to the Surry Difpenfary, and to the Magdalen Hofpital, has practifed vaccine inoculation, and has inoculated between fifty and fixty patients, and in no one inftance had any fymptoms occurred injurious to the part inoculated, or conftitution of the patients; and he believes them to be completely fecure from the fmall-pox. In one particular inftance, the patient, a child of nine months, was covered with a cruft commonly called the crufta lactea, which generally covers the body from head to foot, and had refifted the ufual remedies for that difeafe: but on the tenth day after the infection it began to disappear, and on the twelfth day was wholly gone, during which time not a particle of medi cine was given to it and it continued in perfect health ever fince. (No. 16.) Many other perfons of the first refpectability, gave evidence to the fame effect as thefe we have felected; and Dr. Jenner affured the Committee, that he was prepared to produce any number they might choose to examine. They informed him, that he had established the allegations contained in his petition to their intire fatis-" faction. And it does not appear that any member of the house, when the report was taken into confideration, entertained the fmallest doubt of the Petitioner's claim on the munificence of his country. C 2 For |