Functional Neurobiology of AgingPatrick R. Hof, Charles V. Mobbs Elsevier, 11 янв. 2001 г. - Всего страниц: 960 Some well-known age-related neurological diseases include Parkinson's disease, Alzheimer's disease, deafness, and blindness. Even more common are the problems of aging which are not due to disease but to more subtle impairments in neurobiological systems, including impairments in vision, memory loss, muscle weakening, and loss of reproductive functions, changes in body weight, and sleeplessness. As the average age of our society increases, diseases of aging continue to become more common, and conditions associated with aging need more attention by doctors and researchers. In 1991, patients over the age of 65 saw their doctors an average of eight times per year. Research funding is provided by the Neuroscience and Neuropsychology of Aging (NNA) Program, which is run by the National Institute on Aging. This book offers a comprehensive overview of all topics related to functional impairments which are related to the aging brain and nervous system. It is organized according to four general functions: movement, senses, memory, and neuroendocrine regulation. Written by the leading researchers in the field, this comprehensive work addresses both impairments associated with diseases and not associated with diseases, making it easier to understand the mechanisms involved. Functional Neurobiology of Aging is an important reference for professionals and students involved in aging research, as well as physicians who need to recognize and understand age-related impairments.
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Стр. viii
... Guam Daniel P. Perl I. Introduction 183 II. Clinical Features 184 III. Amyotrophic Lateral Sclerosis of Guam (or the Marianas Form of ALS) 185 IV. Parkinsonism±Dementia Complex of Guam 185 V. Marianas Dementia 185 VI. Neuropathologic ...
... Guam Daniel P. Perl I. Introduction 183 II. Clinical Features 184 III. Amyotrophic Lateral Sclerosis of Guam (or the Marianas Form of ALS) 185 IV. Parkinsonism±Dementia Complex of Guam 185 V. Marianas Dementia 185 VI. Neuropathologic ...
Стр. 43
... Guam, and parkinsonism accompanying distinct neurological disorders (National Institutes of Health, 1994). The Europarkinson collaborative study separated the various forms of parkinsonism by frequency of occurrence and found that after ...
... Guam, and parkinsonism accompanying distinct neurological disorders (National Institutes of Health, 1994). The Europarkinson collaborative study separated the various forms of parkinsonism by frequency of occurrence and found that after ...
Стр. 70
... Guam amyotrophic lateral sclerosis (Figs. 6.4c and 6.4d). Ultrastructurally, a conspicuous lack of endothelial cells in microvessels, as well as a signi®cant increase in the number of normally occurring gaps in endothelial continuity ...
... Guam amyotrophic lateral sclerosis (Figs. 6.4c and 6.4d). Ultrastructurally, a conspicuous lack of endothelial cells in microvessels, as well as a signi®cant increase in the number of normally occurring gaps in endothelial continuity ...
Стр. 107
... Guam: Quantitative neuropathology, immunohistochemical analysis of neuronal vulnerability, and comparison with related neurodegenerative disorders. Acta Neuropathol. 88, 397±404. Hof, P. R., Mufson, E. J., and Morrison, J. H. (1995a) ...
... Guam: Quantitative neuropathology, immunohistochemical analysis of neuronal vulnerability, and comparison with related neurodegenerative disorders. Acta Neuropathol. 88, 397±404. Hof, P. R., Mufson, E. J., and Morrison, J. H. (1995a) ...
Стр. 149
... Guam, Niemann± Pick disease type C, myotonic dystrophy, subacute sclerosing panencephalitis, and postencephalitic parkinsonism (for review, see Tolnay and Probst, 1999). Early language impairment, frontal symptoms, and personality ...
... Guam, Niemann± Pick disease type C, myotonic dystrophy, subacute sclerosing panencephalitis, and postencephalitic parkinsonism (for review, see Tolnay and Probst, 1999). Early language impairment, frontal symptoms, and personality ...
Содержание
1 | |
51 | |
Senses Sensory Cortices and Primary Afferent Functions | 493 |
Locomotion Basal Ganglia and Muscular Functions | 659 |
Homeostasis Hypothalamus and Related Systems | 737 |
Appendix Basic Genetic Concepts | 941 |
Index | 947 |
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abnormal Acad Acta Neuropathol activity age-related aged monkeys Alzheimer's disease amyloid precursor protein amyotrophic lateral animals antibodies apolipoprotein associated basal forebrain behavioral binding Braak Brain Res cell cerebral cortex changes cholinergic cholinergic basal forebrain cingulate clinical correlation cortical de®cits decrease degeneration Delacourte density deposits disorders elderly entorhinal cortex estrogen factors frontal function gene genetic glucose glutamate receptor Guam hippocampus human identi®ed immunoreactivity in¯uence increased layer lesions Lewy body lobe Mattson memory metabolic Morrison Mufson mutations Natl ndings neocortex neocortical neurites neuro®brillary tangles neuro®lament Neurobiol Neurochem neurodegeneration Neurology neuronal loss Neurosci NMDA receptor nucleus basalis observed Parkinson's disease pathology patients peptide phosphorylation Pick's disease presenilin primate progressive supranuclear palsy re¯ect regions rhesus risk role senile plaques signi®cant signi®cantly spatial speci®c stroke studies subtypes synaptic synuclein task tau proteins temporal tion transgenic mice vascular dementia visual
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