Functional Neurobiology of AgingPatrick R. Hof, Charles V. Mobbs Elsevier, 11 янв. 2001 г. - Всего страниц: 960 Some well-known age-related neurological diseases include Parkinson's disease, Alzheimer's disease, deafness, and blindness. Even more common are the problems of aging which are not due to disease but to more subtle impairments in neurobiological systems, including impairments in vision, memory loss, muscle weakening, and loss of reproductive functions, changes in body weight, and sleeplessness. As the average age of our society increases, diseases of aging continue to become more common, and conditions associated with aging need more attention by doctors and researchers. In 1991, patients over the age of 65 saw their doctors an average of eight times per year. Research funding is provided by the Neuroscience and Neuropsychology of Aging (NNA) Program, which is run by the National Institute on Aging. This book offers a comprehensive overview of all topics related to functional impairments which are related to the aging brain and nervous system. It is organized according to four general functions: movement, senses, memory, and neuroendocrine regulation. Written by the leading researchers in the field, this comprehensive work addresses both impairments associated with diseases and not associated with diseases, making it easier to understand the mechanisms involved. Functional Neurobiology of Aging is an important reference for professionals and students involved in aging research, as well as physicians who need to recognize and understand age-related impairments.
|
Результаты поиска по книге
Результаты 1 – 5 из 72
Стр. xiv
... Age-Related Hearing Loss 555 IV. Acoustic Trauma and Age-Related Hearing Loss 555 A. Animal Models of Noise-Induced Hearing Loss and Age-Related 549 553 554 Hearing Loss 556 B. Mechanism of Hearing Loss 557 C. Aging and Susceptibility ...
... Age-Related Hearing Loss 555 IV. Acoustic Trauma and Age-Related Hearing Loss 555 A. Animal Models of Noise-Induced Hearing Loss and Age-Related 549 553 554 Hearing Loss 556 B. Mechanism of Hearing Loss 557 C. Aging and Susceptibility ...
Стр. 13
... relative contribution of genotype to the total incidence of most diseases decreases after about age 70. Similarly, the contribution of genotype to nonpathological age-related neurobiological impairments also appears to peak at about 70 ...
... relative contribution of genotype to the total incidence of most diseases decreases after about age 70. Similarly, the contribution of genotype to nonpathological age-related neurobiological impairments also appears to peak at about 70 ...
Стр. 14
... age, for example due to profound age-related differences in exposure to drugs. Nevertheless, despite these complications, there has been remarkable agreement concerning the relationship between environment and heredity during aging in ...
... age, for example due to profound age-related differences in exposure to drugs. Nevertheless, despite these complications, there has been remarkable agreement concerning the relationship between environment and heredity during aging in ...
Стр. 17
... age and gender) was 80%. In a detailed review of studies from both the ... age 70 years. A further analysis of the Swedish twin study appeared to corroborate this ... related impairments in sensory functions may also involve genetic ...
... age and gender) was 80%. In a detailed review of studies from both the ... age 70 years. A further analysis of the Swedish twin study appeared to corroborate this ... related impairments in sensory functions may also involve genetic ...
Стр. 22
... aging (Keck and Lakoski, 2000). Interestingly, de®ciencies of 5-HT1A receptors have been observed in cortical tissue from patients diagnosed with the age-related disorder Alzheimer's disease (Middlemiss et al., 1986). This diversity in age ...
... aging (Keck and Lakoski, 2000). Interestingly, de®ciencies of 5-HT1A receptors have been observed in cortical tissue from patients diagnosed with the age-related disorder Alzheimer's disease (Middlemiss et al., 1986). This diversity in age ...
Содержание
1 | |
51 | |
Senses Sensory Cortices and Primary Afferent Functions | 493 |
Locomotion Basal Ganglia and Muscular Functions | 659 |
Homeostasis Hypothalamus and Related Systems | 737 |
Appendix Basic Genetic Concepts | 941 |
Index | 947 |
Другие издания - Просмотреть все
Часто встречающиеся слова и выражения
abnormal Acad Acta Neuropathol activity age-related aged monkeys Alzheimer's disease amyloid precursor protein amyotrophic lateral animals antibodies apolipoprotein associated basal forebrain behavioral binding Braak Brain Res cell cerebral cortex changes cholinergic cholinergic basal forebrain cingulate clinical correlation cortical de®cits decrease degeneration Delacourte density deposits disorders elderly entorhinal cortex estrogen factors frontal function gene genetic glucose glutamate receptor Guam hippocampus human identi®ed immunoreactivity in¯uence increased layer lesions Lewy body lobe Mattson memory metabolic Morrison Mufson mutations Natl ndings neocortex neocortical neurites neuro®brillary tangles neuro®lament Neurobiol Neurochem neurodegeneration Neurology neuronal loss Neurosci NMDA receptor nucleus basalis observed Parkinson's disease pathology patients peptide phosphorylation Pick's disease presenilin primate progressive supranuclear palsy re¯ect regions rhesus risk role senile plaques signi®cant signi®cantly spatial speci®c stroke studies subtypes synaptic synuclein task tau proteins temporal tion transgenic mice vascular dementia visual
Популярные отрывки
Стр. 6 - As many more individuals of each species are born than can possibly survive; and as, consequently, there is a frequently recurring struggle for existence, it follows that any being, if it vary however slightly in any manner profitable to itself, under the complex and sometimes varying conditions of life, will have a better chance of surviving, and thus be naturally selected. From the strong principle of inheritance, any selected variety will tend to propagate its new and modified form.
Стр. 129 - Scheuner D, Eckman C, Jensen M, Song X, Citron M, Suzuki N, Bird TD, Hardy J, Hutton M, Kukull W, Larson E, LevyLahad E, Viitanen M, Peskind E, Poorkaj P, Schellenberg G, Tanzi R, Wasco W, Lannfelt L, Selkoe D...
Стр. 83 - R. (1991) Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment.
Стр. 153 - Hutton M, Lendon CL, Rizzu P, Baker M, Froelich S, Houlden H, Pickering-Brown S, Chakraverty S, Isaacs A, Grover A, Hackett J, Adamson J, Lincoln S, Dickson D, Davies P, Petersen RC, Stevens M, de Graaff E, Wauters E, van Baren J, Hillebrand M, Joosse M, Kwon JM, Nowotny P...
Стр. 19 - Polymeropoulos, MH, Lavedan, C., Leroy, E., Ide, SE, Dehejia, A., Dutra, A., Pike, B., Root, H., Rubenstein, J., Boyer, R., Stenroos, ES, Chandrasekharappa, S., Athanassiadou, A., Papapetropoulos, T., Johnson, WG, Lazzarini, AM, Duvoisin, RC, Di lorio, G., Golbe, LI, and Nussbaum, RL, 1997, Mutation in the alpha-synuclein gene identified in families with Parkinson's disease, Science.
Стр. 75 - Oltvai, ZN, Milliman, CL, and Korsmeyer, SJ (1993) Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 74, 609-619.
Стр. 208 - Frackowiak, RSJ, Lenzi, GL, Jones, T. and Heather, JD (1980). 'Quantitative measurement of regional cerebral blood flow and oxygen metabolism in man using 15O and positron emission tomography: theory, procedure and normal values'.
Стр. 404 - Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease.
Стр. 400 - Chartier-Harlin, MC, Crawford, F., Houlden, H., Warren, A., Hughes, D., Fidani, L., Goate, A., Rossor, M., Roques, P.
Стр. 241 - Positron emission tomography and autoradiography: principles and applications for the brain and heart.