Functional Neurobiology of AgingPatrick R. Hof, Charles V. Mobbs Elsevier, 11 янв. 2001 г. - Всего страниц: 960 Some well-known age-related neurological diseases include Parkinson's disease, Alzheimer's disease, deafness, and blindness. Even more common are the problems of aging which are not due to disease but to more subtle impairments in neurobiological systems, including impairments in vision, memory loss, muscle weakening, and loss of reproductive functions, changes in body weight, and sleeplessness. As the average age of our society increases, diseases of aging continue to become more common, and conditions associated with aging need more attention by doctors and researchers. In 1991, patients over the age of 65 saw their doctors an average of eight times per year. Research funding is provided by the Neuroscience and Neuropsychology of Aging (NNA) Program, which is run by the National Institute on Aging. This book offers a comprehensive overview of all topics related to functional impairments which are related to the aging brain and nervous system. It is organized according to four general functions: movement, senses, memory, and neuroendocrine regulation. Written by the leading researchers in the field, this comprehensive work addresses both impairments associated with diseases and not associated with diseases, making it easier to understand the mechanisms involved. Functional Neurobiology of Aging is an important reference for professionals and students involved in aging research, as well as physicians who need to recognize and understand age-related impairments.
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Стр. 6
... correlation between the age-speci®c mortality rate and the relevant age group population size (in 100,000's). correlated with the size of that age group population subset. Similarly, increasing mortality in the elderly from many other ...
... correlation between the age-speci®c mortality rate and the relevant age group population size (in 100,000's). correlated with the size of that age group population subset. Similarly, increasing mortality in the elderly from many other ...
Стр. 7
... correlation coef®cient of the linear regression). Therefore, in 1988 the relationship between Parkinson's disease log Rx and age among U.S. men aged 45 to 80 years was highly linear and, thus by de®nition, Gompertzian. From Eq. (3), the ...
... correlation coef®cient of the linear regression). Therefore, in 1988 the relationship between Parkinson's disease log Rx and age among U.S. men aged 45 to 80 years was highly linear and, thus by de®nition, Gompertzian. From Eq. (3), the ...
Стр. 8
... correlation coef®cient of the linear regression). Therefore, in 1988 the relationship between log Rx and age for stroke mortality among U.S. white men between age 20 and 85 years was highly linear and, thus by de®nition, Gompertzian ...
... correlation coef®cient of the linear regression). Therefore, in 1988 the relationship between log Rx and age for stroke mortality among U.S. white men between age 20 and 85 years was highly linear and, thus by de®nition, Gompertzian ...
Стр. 15
... correlated with age of onset of Huntington's disease early in life, but the strength of this correlation decreases with age (Crauford and Dodge, 1993; Kremer et al., 1993). Therefore the coupling between genotype and the age of onset of ...
... correlated with age of onset of Huntington's disease early in life, but the strength of this correlation decreases with age (Crauford and Dodge, 1993; Kremer et al., 1993). Therefore the coupling between genotype and the age of onset of ...
Стр. 68
... correlation between the regional distribution of NFT and SP within the cerebral cortex, at least at the early stages of the degenerative process (Giannakopoulos et al., 1993; van de Nes et al., 1998). One can conclude that although ...
... correlation between the regional distribution of NFT and SP within the cerebral cortex, at least at the early stages of the degenerative process (Giannakopoulos et al., 1993; van de Nes et al., 1998). One can conclude that although ...
Содержание
1 | |
51 | |
Senses Sensory Cortices and Primary Afferent Functions | 493 |
Locomotion Basal Ganglia and Muscular Functions | 659 |
Homeostasis Hypothalamus and Related Systems | 737 |
Appendix Basic Genetic Concepts | 941 |
Index | 947 |
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abnormal Acad Acta Neuropathol activity age-related aged monkeys Alzheimer's disease amyloid precursor protein amyotrophic lateral animals antibodies apolipoprotein associated basal forebrain behavioral binding Braak Brain Res cell cerebral cortex changes cholinergic cholinergic basal forebrain cingulate clinical correlation cortical de®cits decrease degeneration Delacourte density deposits disorders elderly entorhinal cortex estrogen factors frontal function gene genetic glucose glutamate receptor Guam hippocampus human identi®ed immunoreactivity in¯uence increased layer lesions Lewy body lobe Mattson memory metabolic Morrison Mufson mutations Natl ndings neocortex neocortical neurites neuro®brillary tangles neuro®lament Neurobiol Neurochem neurodegeneration Neurology neuronal loss Neurosci NMDA receptor nucleus basalis observed Parkinson's disease pathology patients peptide phosphorylation Pick's disease presenilin primate progressive supranuclear palsy re¯ect regions rhesus risk role senile plaques signi®cant signi®cantly spatial speci®c stroke studies subtypes synaptic synuclein task tau proteins temporal tion transgenic mice vascular dementia visual
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