Functional Neurobiology of AgingPatrick R. Hof, Charles V. Mobbs Elsevier, 11 янв. 2001 г. - Всего страниц: 960 Some well-known age-related neurological diseases include Parkinson's disease, Alzheimer's disease, deafness, and blindness. Even more common are the problems of aging which are not due to disease but to more subtle impairments in neurobiological systems, including impairments in vision, memory loss, muscle weakening, and loss of reproductive functions, changes in body weight, and sleeplessness. As the average age of our society increases, diseases of aging continue to become more common, and conditions associated with aging need more attention by doctors and researchers. In 1991, patients over the age of 65 saw their doctors an average of eight times per year. Research funding is provided by the Neuroscience and Neuropsychology of Aging (NNA) Program, which is run by the National Institute on Aging. This book offers a comprehensive overview of all topics related to functional impairments which are related to the aging brain and nervous system. It is organized according to four general functions: movement, senses, memory, and neuroendocrine regulation. Written by the leading researchers in the field, this comprehensive work addresses both impairments associated with diseases and not associated with diseases, making it easier to understand the mechanisms involved. Functional Neurobiology of Aging is an important reference for professionals and students involved in aging research, as well as physicians who need to recognize and understand age-related impairments.
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Стр. 19
... ed.), pp. 399±425. Saunders, Philadelphia. Lunkes, A., Trottier, Y., and Mandel, J. L. (1998). Pathological ... identi®ed in families with Parkinson's disease. Science 276, 2045±2047. Raiha, I., Kaprio, J., Koskenvuo, M., Rajala, T., and ...
... ed.), pp. 399±425. Saunders, Philadelphia. Lunkes, A., Trottier, Y., and Mandel, J. L. (1998). Pathological ... identi®ed in families with Parkinson's disease. Science 276, 2045±2047. Raiha, I., Kaprio, J., Koskenvuo, M., Rajala, T., and ...
Стр. 45
... identi®cation of drug-induced and other chemical injury forms of parkinsonism. Research intensi®ed following the discovery in the mid-1980s of parkinsonism among heroin users who had been exposed to the street drug contaminant 1-methyl ...
... identi®cation of drug-induced and other chemical injury forms of parkinsonism. Research intensi®ed following the discovery in the mid-1980s of parkinsonism among heroin users who had been exposed to the street drug contaminant 1-methyl ...
Стр. 53
... identi®ed interact with each other almost constantly and others appear to operate relatively independently. This chapter provides a general overview of the human memory system and describes how the various aspects of memory change ...
... identi®ed interact with each other almost constantly and others appear to operate relatively independently. This chapter provides a general overview of the human memory system and describes how the various aspects of memory change ...
Стр. 66
... identi®ed by immunocytochemistry using both ALZ-50 and anti-PHF antibodies. Neuropil threads are abnormal neuronal processes that contain both PHF and straight ®laments. They are mainly located in distal segments of axons and dendrites ...
... identi®ed by immunocytochemistry using both ALZ-50 and anti-PHF antibodies. Neuropil threads are abnormal neuronal processes that contain both PHF and straight ®laments. They are mainly located in distal segments of axons and dendrites ...
Стр. 69
... identi®ed. Among the pyramidal neurons of the hippocampal formation, cell death appears closely related to the presence of NFT, many of which are visualized in the neuropil when the neuronal nucleus and cytoplasm disappear. In ...
... identi®ed. Among the pyramidal neurons of the hippocampal formation, cell death appears closely related to the presence of NFT, many of which are visualized in the neuropil when the neuronal nucleus and cytoplasm disappear. In ...
Содержание
1 | |
51 | |
Senses Sensory Cortices and Primary Afferent Functions | 493 |
Locomotion Basal Ganglia and Muscular Functions | 659 |
Homeostasis Hypothalamus and Related Systems | 737 |
Appendix Basic Genetic Concepts | 941 |
Index | 947 |
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abnormal Acad Acta Neuropathol activity age-related aged monkeys Alzheimer's disease amyloid precursor protein amyotrophic lateral animals antibodies apolipoprotein associated basal forebrain behavioral binding Braak Brain Res cell cerebral cortex changes cholinergic cholinergic basal forebrain cingulate clinical correlation cortical de®cits decrease degeneration Delacourte density deposits disorders elderly entorhinal cortex estrogen factors frontal function gene genetic glucose glutamate receptor Guam hippocampus human identi®ed immunoreactivity in¯uence increased layer lesions Lewy body lobe Mattson memory metabolic Morrison Mufson mutations Natl ndings neocortex neocortical neurites neuro®brillary tangles neuro®lament Neurobiol Neurochem neurodegeneration Neurology neuronal loss Neurosci NMDA receptor nucleus basalis observed Parkinson's disease pathology patients peptide phosphorylation Pick's disease presenilin primate progressive supranuclear palsy re¯ect regions rhesus risk role senile plaques signi®cant signi®cantly spatial speci®c stroke studies subtypes synaptic synuclein task tau proteins temporal tion transgenic mice vascular dementia visual
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