Functional Neurobiology of AgingPatrick R. Hof, Charles V. Mobbs Elsevier, 11 янв. 2001 г. - Всего страниц: 960 Some well-known age-related neurological diseases include Parkinson's disease, Alzheimer's disease, deafness, and blindness. Even more common are the problems of aging which are not due to disease but to more subtle impairments in neurobiological systems, including impairments in vision, memory loss, muscle weakening, and loss of reproductive functions, changes in body weight, and sleeplessness. As the average age of our society increases, diseases of aging continue to become more common, and conditions associated with aging need more attention by doctors and researchers. In 1991, patients over the age of 65 saw their doctors an average of eight times per year. Research funding is provided by the Neuroscience and Neuropsychology of Aging (NNA) Program, which is run by the National Institute on Aging. This book offers a comprehensive overview of all topics related to functional impairments which are related to the aging brain and nervous system. It is organized according to four general functions: movement, senses, memory, and neuroendocrine regulation. Written by the leading researchers in the field, this comprehensive work addresses both impairments associated with diseases and not associated with diseases, making it easier to understand the mechanisms involved. Functional Neurobiology of Aging is an important reference for professionals and students involved in aging research, as well as physicians who need to recognize and understand age-related impairments.
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Стр. 14
... observation that the optimum score for objective health was observed in individuals at all age ranges, but the worst reported score for health increased with the age of the group. In contrast, effects of age on height and weight were ...
... observation that the optimum score for objective health was observed in individuals at all age ranges, but the worst reported score for health increased with the age of the group. In contrast, effects of age on height and weight were ...
Стр. 16
... observed, and in 15% of such families, allelic variations of the -amyloid precursor were observed. In contrast, in nine families that did not exhibit an early-onset form of the Alzheimer's disease, such allelic variations were not ...
... observed, and in 15% of such families, allelic variations of the -amyloid precursor were observed. In contrast, in nine families that did not exhibit an early-onset form of the Alzheimer's disease, such allelic variations were not ...
Стр. 24
... observed in the cortices of patients with age-related diseases such as Alzheimer's disease (Middlemiss et al., 1986). One explanation for the age-related decline in 5-HT1A receptor af®nity following EEDQ treatment may be that age ...
... observed in the cortices of patients with age-related diseases such as Alzheimer's disease (Middlemiss et al., 1986). One explanation for the age-related decline in 5-HT1A receptor af®nity following EEDQ treatment may be that age ...
Стр. 69
... observed not only in the AD cerebral cortex, but also in some subcortical nuclei, such as the basal nucleus of Meynert, locus coeruleus, and dorsal raphe (for review, see Terry et al., 1994). The mechanisms surrounding cell death in AD ...
... observed not only in the AD cerebral cortex, but also in some subcortical nuclei, such as the basal nucleus of Meynert, locus coeruleus, and dorsal raphe (for review, see Terry et al., 1994). The mechanisms surrounding cell death in AD ...
Стр. 70
... observed in layers III and VI of the frontal and temporal cortex and correlates with the laminar densities of NFT and SP. In addition, twisted, coiled, and string vessels and glomerular loops have been reported in AD as well as in other ...
... observed in layers III and VI of the frontal and temporal cortex and correlates with the laminar densities of NFT and SP. In addition, twisted, coiled, and string vessels and glomerular loops have been reported in AD as well as in other ...
Содержание
1 | |
51 | |
Senses Sensory Cortices and Primary Afferent Functions | 493 |
Locomotion Basal Ganglia and Muscular Functions | 659 |
Homeostasis Hypothalamus and Related Systems | 737 |
Appendix Basic Genetic Concepts | 941 |
Index | 947 |
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abnormal Acad Acta Neuropathol activity age-related aged monkeys Alzheimer's disease amyloid precursor protein amyotrophic lateral animals antibodies apolipoprotein associated basal forebrain behavioral binding Braak Brain Res cell cerebral cortex changes cholinergic cholinergic basal forebrain cingulate clinical correlation cortical de®cits decrease degeneration Delacourte density deposits disorders elderly entorhinal cortex estrogen factors frontal function gene genetic glucose glutamate receptor Guam hippocampus human identi®ed immunoreactivity in¯uence increased layer lesions Lewy body lobe Mattson memory metabolic Morrison Mufson mutations Natl ndings neocortex neocortical neurites neuro®brillary tangles neuro®lament Neurobiol Neurochem neurodegeneration Neurology neuronal loss Neurosci NMDA receptor nucleus basalis observed Parkinson's disease pathology patients peptide phosphorylation Pick's disease presenilin primate progressive supranuclear palsy re¯ect regions rhesus risk role senile plaques signi®cant signi®cantly spatial speci®c stroke studies subtypes synaptic synuclein task tau proteins temporal tion transgenic mice vascular dementia visual
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