Notch from Neurodevelopment to Neurodegeneration: Keeping the FateA. Israel, B. de Strooper, F. Checler, Y. Christen Springer Science & Business Media, 6 дек. 2012 г. - Всего страниц: 158 Can molecular mechanisms involved in neural development help us to understand, prevent and perhaps reverse the course of brain ageing and neurodegenerative disorders? Brain development and function require complex cellular and molecular processes controlled by a number of different signaling mechanisms. One such signaling mechanism, the Notch pathway, has been recognized as an important player in the regulation of cellfate decisions during early neural development. However, the action of this evolutionary conserved and widely used cell-cell interaction mechanism is not confined to the developing nervous system. In addition, recent studies have shown that elucidating the mechanism of Notch signaling and its role in the brain is important for our understanding of neurological disorders such as Alzheimer's disease and cerebral arteriopathy CADASIL. |
Содержание
More than Just a Developmental | |
Conclusion | |
Results | |
Discussion | |
New NonPeptidic Inhibitors of γSecretase Abolish | |
Acknowledgements | |
Conclusion | |
βAPP Processing its Biology and Alzheimers Disease | |
References | |
Both Wildtype PS1 and PS1Δcat Restore Normal Proteolytic | |
Neuroanatomical localization of δcatenin | |
Vascular Smooth Muscle Cells Are the Primary Target of | |
Conclusion and Perspectives | |
Другие издания - Просмотреть все
Notch from Neurodevelopment to Neurodegeneration: Keeping the Fate Alain Israel,B. de Strooper,F. Checler,Y. Christen Ограниченный просмотр - 2002 |
Notch from Neurodevelopment to Neurodegeneration: Keeping the Fate Alain Israel,B. de Strooper,F. Checler,Y. Christen Недоступно для просмотра - 2012 |
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Acad Sci USA Alzheimer’s disease amino acids amyloid precursor protein Annaert antibodies APP and Notch ArtavanisTsakonas aspartates aspartyl protease assay ATF6 binding Biol Chem brain CADASIL cadherin catenin Cell Biol cellular cleavage cleavage of Notch cleaved complex Cterminal cytosolic detected Drosophila elegans encoding endoproteolysis enzyme expression Fbox fragment function gammasecretase genes Goldstein JL Golgi Greenwald Haass HEK293 cells homologue immunoprecipitated inhibition inhibitors interaction Kopan Levesque ligand mammalian mediates membranespanning domain Mol Cell molecular molecule Mumm mutations Natl Acad Sci neurite neurogenesis neurons Neurosci NIC nicastrin NICD Nohturfft Notch intracellular domain Notch receptors Notch signaling nuclear overexpressing phenotype phosphorylation presenilin Proc Natl Acad production proteasome proteolytic Ray WJ regulated residues Rogaeva role Saftig SCAP Schroeter EH secretase Selkoe DJ sequence signal peptide SREBP St GeorgeHyslop stably sterols Strooper substrate Thinakaran transcription factor transfected translocation transmembrane domain ubiquitin wildtype Wolfe Zhang