Proteases as Targets for Therapy

3C proteinases 6-strand Acad Sci USA active-site adenovirus agents amino acids amyloid antiretroviral antiviral apoptosis assays bacterial batimastat binding Biochem Biochemistry Biol Chem C-terminal cancer caspase catalytic efficiency catalytic triad cathepsin cells chymotrypsin-like cleavage sites cleaved clinical complex compounds crystal structure cystatin cysteine proteinase disease domain drug effect elastase enzyme factor Xa function gene gingipains hepatitis C virus herpes HIV protease human immunodeficiency virus identified immunodeficiency virus type increase indinavir infection inhibition interactions matrix metalloproteinase molecular molecule mutations Natl Acad Sci nelfinavir neutrophil NS3 proteinase NS4A oxyanion pathogens pathway patients peptidases peptide plasma polyprotein potent Proc Natl Acad protease inhibitors proteasome proteolytic proteolytic enzymes pVIc receptor regimens replication residues resistance ritonavir role saquinavir sequence serine proteinase side chain specific stefin strategy studies substrate TACE target teinase therapeutic therapy thrombin tion tissue tumor viral load Virol Virology viruses vitro vivo Y-secretase