Proteases as Targets for TherapyKlaus, von der Helm, Bruce D. Korant, John C. Cheronis Springer Science & Business Media, 6 дек. 2012 г. - Всего страниц: 410 With contributions by numerous experts |
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Стр. xx
... . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 121 I. The Picornaviral Life Cycle . . . . . . . . . . . . . . . . . . . . . . . . . . . . 121 II. Proteolytic Processing of the Viral Polyprotein . . . XX Contents.
... . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 121 I. The Picornaviral Life Cycle . . . . . . . . . . . . . . . . . . . . . . . . . . . . 121 II. Proteolytic Processing of the Viral Polyprotein . . . XX Contents.
Стр. xxi
... Polyprotein . . . . . . . . . . . 123 III. Regulation of Capsid Assembly by Proteolytic Cleavages of the Capsid-Protein Precursors . . . . . . . . . . . . . . . . . . . . . . . 124 IV. Inhibition of Cellular Functions by Proteolytic ...
... Polyprotein . . . . . . . . . . . 123 III. Regulation of Capsid Assembly by Proteolytic Cleavages of the Capsid-Protein Precursors . . . . . . . . . . . . . . . . . . . . . . . 124 IV. Inhibition of Cellular Functions by Proteolytic ...
Стр. 4
... polyproteins which are subsequently processed into mature proteins by a protease, which is itself encoded within the gag-pol polyprotein (Fig. 1). Molecular cloning and sequence determination of the HIV genome revealed the presence of ...
... polyproteins which are subsequently processed into mature proteins by a protease, which is itself encoded within the gag-pol polyprotein (Fig. 1). Molecular cloning and sequence determination of the HIV genome revealed the presence of ...
Стр. 6
... polyprotein was observed. This processing was completely prevented by a frameshift mutation in the protease region ... polyproteins, but had not yet been proven to be essential for viral infectivity. It was against this background that ...
... polyprotein was observed. This processing was completely prevented by a frameshift mutation in the protease region ... polyproteins, but had not yet been proven to be essential for viral infectivity. It was against this background that ...
Стр. 7
... polyprotein, was a reasonable substrate (Km = 1.42 mM). Importantly, we were also able to establish that the peptide was cleaved between the tyrosine and proline residues, as we had hoped. This peptide, together with a related ...
... polyprotein, was a reasonable substrate (Km = 1.42 mM). Importantly, we were also able to establish that the peptide was cleaved between the tyrosine and proline residues, as we had hoped. This peptide, together with a related ...
Содержание
6 | |
10 | |
13 | |
B Activity on Immunological and Virological Markers | 24 |
References | 30 |
Biochemical Basis for Resistance | 38 |
References | 44 |
Two Strategies to Reduce Viral Resistance to PIs | 50 |
General Considerations in the Development of MMPIs | 224 |
G Conclusions | 231 |
Structural Features of TACE | 238 |
Inhibitors of TACE and TNFO Secretion | 245 |
TACE and Membrane Protein Secretases | 251 |
Neutrophil Elastase | 260 |
B Serine Elastases and Inflammation | 262 |
Potential Clinical Targets for SerineElastase Inhibition | 268 |
Designing Drugs to Inhibit PIResistant Viruses | 56 |
Suggestions for Future Therapeutic Strategies | 66 |
CHAPTER 5 | 77 |
The NS23 Proteinase | 87 |
B Background | 96 |
Substrates | 105 |
References | 111 |
B Picornaviridae | 118 |
E The 3C Proteinases | 125 |
F Inhibition of 3C Proteinases | 132 |
Roles of AVP Cofactors in Virus Maturation | 149 |
E Summary and Prospects | 155 |
E Paradigms for Testing Proteinase Inhibitors as Therapeutic | 173 |
F Bacterial Proteinases to the Rescue | 179 |
Parasite Proteases as Targets for Therapy | 189 |
Serine Proteases | 198 |
B History | 212 |
A Introduction 221 | 222 |
B Thrombin Inhibitors | 280 |
FactorXa Inhibitors | 289 |
A Introduction 301 | 302 |
Cystatins in Cancer | 310 |
Potential Transcriptional Regulation | 316 |
Lessons Learned from Natural Caspase Inhibitors | 330 |
H Conclusions | 336 |
Ubiquitination and Cell Cycle | 343 |
Regulatory Control of Ub and the Proteasome in Apoptosis | 346 |
F The UbProteasome System and Cancer Therapy | 353 |
B Molecular Biology of AD | 360 |
References | 370 |
EndosomalLysosomal Processing Generates | 376 |
E Proteolytic Degradation of PSs | 384 |
New Targets for AntiAmyloidogenic Drugs? | 390 |
Subject Index 403 | 402 |
Другие издания - Просмотреть все
Proteases as Targets for Therapy, Выпуск 146 Klaus von der Helm,Bruce D. Korant,John Chris Dion Cheronis Ограниченный просмотр - 2000 |
Proteases as Targets for Therapy Klaus, von der Helm,BRUCE KORANT,John C. Cheronis Недоступно для просмотра - 2012 |
Часто встречающиеся слова и выражения
3C proteinases 6-strand Acad Sci USA active-site adenovirus agents amino acids amyloid antiretroviral antiviral apoptosis assays bacterial batimastat binding Biochem Biochemistry Biol Chem C-terminal cancer caspase catalytic efficiency catalytic triad cathepsin cells chymotrypsin-like cleavage sites cleaved clinical complex compounds crystal structure cystatin cysteine proteinase disease domain drug effect elastase enzyme factor Xa function gene gingipains hepatitis C virus herpes HIV protease human immunodeficiency virus identified immunodeficiency virus type increase indinavir infection inhibition interactions matrix metalloproteinase molecular molecule mutations Natl Acad Sci nelfinavir neutrophil NS3 proteinase NS4A oxyanion pathogens pathway patients peptidases peptide plasma polyprotein potent Proc Natl Acad protease inhibitors proteasome proteolytic proteolytic enzymes pVIc receptor regimens replication residues resistance ritonavir role saquinavir sequence serine proteinase side chain specific stefin strategy studies substrate TACE target teinase therapeutic therapy thrombin tion tissue tumor viral load Virol Virology viruses vitro vivo Y-secretase