Science, Том 314,Выпуски 5796-5801John Michels (Journalist) American Association for the Advancement of Science, 2006 |
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Стр. 295
... FOXO1 ( S249A and S298A ) that make it impervious to CDK2- mediated phosphorylation enhanced the activity of FOXO1 - AAA , and the inhibitory effect of Fig . 1. CDK2 phos- phorylates FOX01 at Ser249 in vitro . ( A ) Sche- matic diagram ...
... FOXO1 ( S249A and S298A ) that make it impervious to CDK2- mediated phosphorylation enhanced the activity of FOXO1 - AAA , and the inhibitory effect of Fig . 1. CDK2 phos- phorylates FOX01 at Ser249 in vitro . ( A ) Sche- matic diagram ...
Стр. 296
John Michels (Journalist). mic localization of wild - type FOXO1 but not the phosphorylation - resistant mutant S249A of FOXO1 ( Fig . 3 , C and D ) , suggesting that CDK2 - induced trafficking of FOXO1 from the nucleus to the cytoplasm ...
John Michels (Journalist). mic localization of wild - type FOXO1 but not the phosphorylation - resistant mutant S249A of FOXO1 ( Fig . 3 , C and D ) , suggesting that CDK2 - induced trafficking of FOXO1 from the nucleus to the cytoplasm ...
Стр. 297
... FOXO1 phosphorylation at Ser249 , we silenced endoge- nous Chkl in LNCaP cells or treated them with the Chkl inhibitor UCN - 01 . Not only did the basal amount of FOXO1 phosphorylation at Ser249 increase , but the camptothecin - induced ...
... FOXO1 phosphorylation at Ser249 , we silenced endoge- nous Chkl in LNCaP cells or treated them with the Chkl inhibitor UCN - 01 . Not only did the basal amount of FOXO1 phosphorylation at Ser249 increase , but the camptothecin - induced ...
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