Science, Том 314,Выпуски 5796-5801John Michels (Journalist) American Association for the Advancement of Science, 2006 |
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Стр. 269
... mutations 816,986 putative mutations observed Resequence tumor DNA to confirm remaining 29,281 mutations Sequence patient - matched DNA from normal cells to determine whether remaining 19,986 mutations were somatic 1,307 somatic ...
... mutations 816,986 putative mutations observed Resequence tumor DNA to confirm remaining 29,281 mutations Sequence patient - matched DNA from normal cells to determine whether remaining 19,986 mutations were somatic 1,307 somatic ...
Стр. 270
... mutations within 4 bp of exon / intron boundary . IINucleotides with Phred quality score of at least 20 . † Genes mutated in the discovery screen were sequenced in 24 §Mutations in untranslated regions ( UTR ) within 4 bp 5 ′ of ...
... mutations within 4 bp of exon / intron boundary . IINucleotides with Phred quality score of at least 20 . † Genes mutated in the discovery screen were sequenced in 24 §Mutations in untranslated regions ( UTR ) within 4 bp 5 ′ of ...
Стр. 273
... mutations exert comparable effects on cells , as do mutations in RB1 , CDKN2A ( p16 ) , CCNDI , and CDK4 . It will be of interest to de- termine whether a limited number of pathways include most CAN genes , a possibility consistent with ...
... mutations exert comparable effects on cells , as do mutations in RB1 , CDKN2A ( p16 ) , CCNDI , and CDK4 . It will be of interest to de- termine whether a limited number of pathways include most CAN genes , a possibility consistent with ...
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