Science, Том 293John Michels (Journalist) American Association for the Advancement of Science, 2001 |
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Стр. 879
... mutation should not interfere with ATP binding ( 32 ) . To confirm that this amino acid substitution interferes with STI - 571 activity , we engineered the T3151 mutation into wild - type p210 BCR- ABL ( 33 ) . Cells were transfected ...
... mutation should not interfere with ATP binding ( 32 ) . To confirm that this amino acid substitution interferes with STI - 571 activity , we engineered the T3151 mutation into wild - type p210 BCR- ABL ( 33 ) . Cells were transfected ...
Стр. 1158
... mutations sug- gested by docking of b12 onto gp120 were mapped onto the gp120 surface . Mutation of residues in blue enhances b12 binding ( > 200 % affinity relative to wild type ) ; mutations in red diminish b12 binding ( < 50 ...
... mutations sug- gested by docking of b12 onto gp120 were mapped onto the gp120 surface . Mutation of residues in blue enhances b12 binding ( > 200 % affinity relative to wild type ) ; mutations in red diminish b12 binding ( < 50 ...
Стр. 1671
... mutant . This mutation results in an Ile - to - Asp substitution at residue 331. ( C ) Ile - 331 sits in a nonpolar pocket of the enzyme as illustrated in these rasmol images of the bovine UGDH crystal structure ( 12 , 38 ) . The Ile is ...
... mutant . This mutation results in an Ile - to - Asp substitution at residue 331. ( C ) Ile - 331 sits in a nonpolar pocket of the enzyme as illustrated in these rasmol images of the bovine UGDH crystal structure ( 12 , 38 ) . The Ile is ...
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acetylation acid activity allele analysis animals antibody apoptosis applications areas assays associated binding Biochemistry bioinformatics Biol Cancer candidate cell biology cellular Center centromeric chemical chemistry chromatin chromosome clinical cloning curriculum vitae Department Dicer disease DNA methylation Drosophila drug discovery dsRNA E-mail electron embryos enhanceosome enzyme epigenetic Equal Opportunity Employer experience faculty function gene expression genetic genome heterochromatin histone histone H3 HMGI(Y human Immunology imprinted Institute interactions Job Code kinase laboratory Medical Medicine ment molecular biology molecules mouse mRNA mutation nuclear nucleosomes nucleus O₂ optical organic peptide perylene Ph.D pharmaceutical Pharmacology phosphorylation plants POSTDOCTORAL POSITION potential PRMT1 probe protein receptor region regulation RNAi says Science scientists send curriculum vitae sequence Service Card siRNAs structure target three references tion toxin transcription transfected transposons Univ University vitro vivo