Science, Том 292John Michels (Journalist) American Association for the Advancement of Science, 2001 |
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Стр. 1852
... MDM2 MDM2 p53 p53 Ubiquitination MDM2 Degradation of p53 Coactivators p53 Stressed cell T Cytoplasm MDM2 Location is key . ( Left ) In unstressed cells , both p53 and MDM2 shuttle between the nucleus and the cytoplasm . When they form a ...
... MDM2 MDM2 p53 p53 Ubiquitination MDM2 Degradation of p53 Coactivators p53 Stressed cell T Cytoplasm MDM2 Location is key . ( Left ) In unstressed cells , both p53 and MDM2 shuttle between the nucleus and the cytoplasm . When they form a ...
Стр. 1911
... MDM2 ( 10 , 11 ) , underscoring the importance of nuclear export in regulating p53 stability . The mechanism governing p53 nuclear export remains unclear , and three competing models have been proposed ( 12 ) . MDM2 may bind p53 in the ...
... MDM2 ( 10 , 11 ) , underscoring the importance of nuclear export in regulating p53 stability . The mechanism governing p53 nuclear export remains unclear , and three competing models have been proposed ( 12 ) . MDM2 may bind p53 in the ...
Стр. 1912
... MDM2 - independent p53 nuclear export . ( A ) p53 - / -- MDM2 - / - MEFS ( 2KO ) were infected with adenovirus expressing p53 . Twenty hours after transfection , cells were fused with p53 - deficient human Saos - 2 cells that had been ...
... MDM2 - independent p53 nuclear export . ( A ) p53 - / -- MDM2 - / - MEFS ( 2KO ) were infected with adenovirus expressing p53 . Twenty hours after transfection , cells were fused with p53 - deficient human Saos - 2 cells that had been ...
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