Protein Misfolding in Neurodegenerative Diseases: Mechanisms and Therapeutic StrategiesRobert D. E. Sewell CRC Press, 3 дек. 2007 г. - Всего страниц: 592 Current research suggests that neurodegenerative diseases such as Alzheimer's, Parkinson's, Huntington's, and Creutzfeldt-Jacob may be linked to disorders in protein shape referred to as protein misfolding. Continued study in this area could lead to promising advances in future treatment of these diseases. This groundbreaking text describes the latest findings regarding protein misfolding in the context of it being a marker, and perhaps a cause, in neurodegenerative diseases. Comprehensive coverage includes the diverse biochemical targets/markers for each disease, the currently limited success of drug therapies, and the cutting-edge research that could lead to more promising treatments. |
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Стр. 1
... protein folding thus highlighting key issues in the closely linked areas of protein misfolding and aggregation. Presently, protein folding and protein aggregation are considered in close competition to each other relying on the same ...
... protein folding thus highlighting key issues in the closely linked areas of protein misfolding and aggregation. Presently, protein folding and protein aggregation are considered in close competition to each other relying on the same ...
Стр. 2
... protein aggregates. They also provide a new way to consider the molecular basis of protein misfolding diseases and suggest that protein aggregation into amyloids may be more common in nature than previously believed, as supported by ...
... protein aggregates. They also provide a new way to consider the molecular basis of protein misfolding diseases and suggest that protein aggregation into amyloids may be more common in nature than previously believed, as supported by ...
Стр. 3
Mechanisms and Therapeutic Strategies Robert D. E. Sewell. the molecular basis of protein misfolding and aggregation may help to elucidate the physicochemical features of protein folding and vice versa. It is also expected to shed light ...
Mechanisms and Therapeutic Strategies Robert D. E. Sewell. the molecular basis of protein misfolding and aggregation may help to elucidate the physicochemical features of protein folding and vice versa. It is also expected to shed light ...
Стр. 4
... protein folding either in the cytosol or in the endoplasmic reticulum (ER). The evolving information on protein folding, misfolding, aggregation, and aggregate toxicity to living systems is rapidly improving our knowledge on the ...
... protein folding either in the cytosol or in the endoplasmic reticulum (ER). The evolving information on protein folding, misfolding, aggregation, and aggregate toxicity to living systems is rapidly improving our knowledge on the ...
Стр. 7
... protein folding are universal. In any case, environmental conditions such as ... protein polymers. The main physiological function of the molecular chaperones ... aggregation and avoiding any improper interaction with other molecules or ...
... protein folding are universal. In any case, environmental conditions such as ... protein polymers. The main physiological function of the molecular chaperones ... aggregation and avoiding any improper interaction with other molecules or ...
Содержание
1 | |
Chapter 2 Alzheimers Disease | 69 |
Chapter 3 Improving Cholinergic Transmission | 95 |
Chapter 4 Reduction in Plaque Formation | 145 |
Chapter 5 Carbonic Anhydrase Activators as Potential AntiAlzheimers Disease Agents | 265 |
Chapter 6 Detection and Reduction of Neurofibrillary Lesions | 289 |
Pathogenic or Protective? | 327 |
Chapter 8 Enhancement of Brain Retinoic Acid Levels | 337 |
Chapter 10 Restoring Dopamine Levels | 415 |
Chapter 11 Huntingtons Disease | 449 |
Chapter 12 Amyotrophic Lateral Sclerosis Motor Neuron Disease | 479 |
Chapter 13 Transmissible Spongiform Encephalopathies | 517 |
Chapter 14 Overview | 547 |
Index | 557 |
Back cover | 571 |
What Is It? What Causes It? And How Can It Be Cured? | 381 |
Другие издания - Просмотреть все
Protein Misfolding in Neurodegenerative Diseases: Mechanisms and Therapeutic ... Robert D. E. Sewell Недоступно для просмотра - 2019 |
Protein Misfolding in Neurodegenerative Diseases: Mechanisms and Therapeutic ... Robert D. E. Sewell Недоступно для просмотра - 2007 |
Часто встречающиеся слова и выражения
a-synuclein Abeta Academy of Sciences acetylcholinesterase activity Alzheimer disease Alzheimer’s disease amino acid amyloid fibrils amyloid-b amyloidosis amyotrophic lateral sclerosis associated b-amyloid beta-amyloid binding Biological Chemistry brain cell cellular cholesterol clinical cognitive compounds decreased dementia deposition disorders donepezil dopamine dopaminergic drug effects enzyme expression factor filament formation function g-secretase gene Genetics human huntingtin Huntington’s disease increased inhibition inhibitors interaction isoforms Journal of Biological Journal of Neuroscience kinase levels levodopa ligands mechanism Medicinal Chemistry membrane metabolism microtubule modulate Molecular molecules motor neuron mouse model mutations National Academy neurodegenerative Neurology NSAIDs oligomers onset oxidative Parkinson’s disease pathology pathway patients peptide Pharmacology phenotype phosphorylation plaques potential prion disease protein aggregation protein folding PrPSc rasagiline receptor Research retinoic acid retinoid role SOD1 soluble specific statins structure studies substrate Supuran synthesis target tau protein therapeutic therapy tissue toxicity transgenic transgenic mice treatment vitro vivo
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