Cell Surface ProteasesElsevier, 3 мая 2003 г. - Всего страниц: 452 Cell Surface Proteases provides a comprehensive overview of these important enzymes that catalyze the hydrolysis of a protein as it degrades to a simpler substance. In the 1990s, an explosion of new discoveries shed light on the role of cell surface proteases and extended it beyond degradation of extracellular matrix components to include its influence on growth factors, cell signaling, and other cellular events. This volume unites the scientific literature from across disciplines and teases out unified themes of interactions between cell surface proteases and interconnecting cell surface-related systems -- including integrins and other adhesion molecules. Scientists and students involved in developmental biology, cell biology and disease processes will find this an indispensable resource. * Provides an overview of the entire field of cell surface proteases in a single volume* Presents major issues and astonishing discoveries at the forefront of modern developmental biology and developmental medicine * A thematic volume in the longest-running forum for contemporary issues in developmental biology with over 30 years of coverage |
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Стр. 10
... (Seiki, 1999). MT3-MMP is expressed in human placenta, ovary, brain, lung, and vascular smooth muscle cells (Shimada et al., 1999). MT4-MMP is localized in brain, colon, ovary, testis, leukocytes, and in a variety of transformed cell ...
... (Seiki, 1999). MT3-MMP is expressed in human placenta, ovary, brain, lung, and vascular smooth muscle cells (Shimada et al., 1999). MT4-MMP is localized in brain, colon, ovary, testis, leukocytes, and in a variety of transformed cell ...
Стр. 22
... (Seiki, 1999). It has been proposed that activation of NF-kB is essential to induce MT1-MMP expression in fibroblasts after TNF-α exposure (Han et al., 2000). A potential p65 NF-kB binding site in the 5-flanking region of the human and ...
... (Seiki, 1999). It has been proposed that activation of NF-kB is essential to induce MT1-MMP expression in fibroblasts after TNF-α exposure (Han et al., 2000). A potential p65 NF-kB binding site in the 5-flanking region of the human and ...
Стр. 29
... (Seiki, 1999). A second active MT1-MMP molecule on the cell surface then cleaves proMMP-2, leaving highly focused active MMP-2 available for efficient substrate degradation and participation in other events (Butler et al., 1998; Sato et ...
... (Seiki, 1999). A second active MT1-MMP molecule on the cell surface then cleaves proMMP-2, leaving highly focused active MMP-2 available for efficient substrate degradation and participation in other events (Butler et al., 1998; Sato et ...
Стр. 30
... (Seiki, 1999). Although the levels of MT-MMPs translated in the cells were similar, the relative levels of cell surface associated enzyme were different with MT1-MMP>MT3-MMP≫MT2-MMP (Seiki, 1999). A second proMMP-2 binding site on the ...
... (Seiki, 1999). Although the levels of MT-MMPs translated in the cells were similar, the relative levels of cell surface associated enzyme were different with MT1-MMP>MT3-MMP≫MT2-MMP (Seiki, 1999). A second proMMP-2 binding site on the ...
Стр. 43
... Seiki, 1999; Stetler-Stevenson, 1995). In contrast to classical oncogenes, MMPs are not upregulated by gene amplification or activating mutations. The increased MMP expression in tumors is probably due to transcriptional changes rather ...
... Seiki, 1999; Stetler-Stevenson, 1995). In contrast to classical oncogenes, MMPs are not upregulated by gene amplification or activating mutations. The increased MMP expression in tumors is probably due to transcriptional changes rather ...
Содержание
75 | |
Chapter 3 Biochemical Properties and Functions of MembraneAnchored MetalloproteaseDisintegrin Proteins ADAMs | 101 |
Chapter 4 Shedding of Plasma Membrane Proteins | 125 |
Chapter 5 Expression of Meprins in Health and Disease | 145 |
Chapter 6 Type II Transmembrane Serine Proteases | 167 |
Chapter 7 DPPIV Seprase and Related Serine Peptidases in Multiple Cellular Functions | 207 |
Chapter 8 The Secretases of Alzheimers Disease | 233 |
Chapter 9 Plasminogen Activation at the Cell Surface | 263 |
Understanding Its Functional Significance | 313 |
Chapter 11 ProteaseActivated Receptors | 343 |
Chapter 12 Emmprin CD147 a Cell Surface Regulator of Matrix Metalloproteinase Production and Function | 371 |
Implications for Developmental Adaptive Inflammatory and Neoplastic Processes | 391 |
Chapter 14 Shed Membrane Vesicles and Clustering of MembraneBound Proteolytic Enzymes | 411 |
Index | 433 |
Contents of Previous Volumes | 447 |
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Часто встречающиеся слова и выражения
Acad ADAMs adhesion amino acid amyloid angiogenesis astacin binding Biochem breast C-terminal cancer cells Cancer Res carcinoma cells catalytic domain cathepsin cDNA Cell Biol cell lines cell migration cell surface cellular Chem chemokines cleavage cleaved Cloning collagen collagenase complex corin cytoplasmic degradation disease DPPIV emmprin endothelial cells enteropeptidase enzyme expression extracellular matrix fibroblasts fibronectin function gelatinase gene growth factor hepsin human induced inhibition inhibitors integrin interactions invasion involved kinase ligand lysosomes matriptase matrix metalloproteinase mechanism mediated membrane-type meprin metastasis mice MMPs module molecular molecules mouse mRNA MT1-MMP mutations Natl overexpression PAR1 peptidase peptide plasma membrane plasmin plasminogen activation system plasminogen activator platelet potential presenilin processing proMMP-2 protein proteolysis proteolytic receptor regulation residues role secreted Seiki seprase sequence serine protease signaling soluble specific structure substrate subunit TACE thrombin tissue transmembrane tumor tumor cells uPAR urokinase vascular vesicles shed vitro vivo
Популярные отрывки
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Стр. 254 - JJ, et al. (1992) Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the beta-amyloid precursor protein gene.
Стр. 139 - RA, 1998, Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor. J. Biol Chem.
Стр. 252 - Borchelt, DR, Thinakaran, G., Eckman, CB, Lee, MK, Davenport, F., Ratovitsky, T., Prada, CM, Kim, G., Seekins, S., Yager, D., Slunt, HH, Wang, R., Seeger, M., Levey, AI, Gandy, SE, Copeland, NG, Jenkins, NA, Price, DL, Younkin, SG, Sisodia, SS (1996) Familial Alzheimer's disease-linked presenilin 1 variants elevate Aft 1-42/1 -40 ratio in vitro and in vivo.
Стр. 94 - H-ras oncogene-transformed human bronchial epithelial cells (TBE-1) secrete a single metalloprotease capable of degrading basement membrane collagen. J. Biol. Chem., 263, 6579-6587.
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Стр. 144 - Transforming growth factors produced by certain human tumor cells: Polypeptides that interact with epidermal growth factor receptors. Proc.