Cell Surface ProteasesElsevier, 3 мая 2003 г. - Всего страниц: 452 Cell Surface Proteases provides a comprehensive overview of these important enzymes that catalyze the hydrolysis of a protein as it degrades to a simpler substance. In the 1990s, an explosion of new discoveries shed light on the role of cell surface proteases and extended it beyond degradation of extracellular matrix components to include its influence on growth factors, cell signaling, and other cellular events. This volume unites the scientific literature from across disciplines and teases out unified themes of interactions between cell surface proteases and interconnecting cell surface-related systems -- including integrins and other adhesion molecules. Scientists and students involved in developmental biology, cell biology and disease processes will find this an indispensable resource. * Provides an overview of the entire field of cell surface proteases in a single volume* Presents major issues and astonishing discoveries at the forefront of modern developmental biology and developmental medicine * A thematic volume in the longest-running forum for contemporary issues in developmental biology with over 30 years of coverage |
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Стр. vi
... Involved in Ectodomain Shedding 131 IV. How are Substrates Selected? 134 V. Regulation 136 References 138. 5. Expression of Meprins in Health and Disease Lourdes P. Norman, Gail L. Matters, Jacqueline M. Crisman, and Judith S. Bond I ...
... Involved in Ectodomain Shedding 131 IV. How are Substrates Selected? 134 V. Regulation 136 References 138. 5. Expression of Meprins in Health and Disease Lourdes P. Norman, Gail L. Matters, Jacqueline M. Crisman, and Judith S. Bond I ...
Стр. xv
... involved in cleaving other membrane-bound and extracellular matrix proteins, but they are involved in processing physiologically important peptide substrates including growth factors, cytokines, chemokines, hormones, binding proteins ...
... involved in cleaving other membrane-bound and extracellular matrix proteins, but they are involved in processing physiologically important peptide substrates including growth factors, cytokines, chemokines, hormones, binding proteins ...
Стр. xviii
... involved in shedding of cell surface molecules, development, inflammation, and release of signaling molecules. Memapsin 2 and presenilins are associated with Alzheimer's disease. Membrane vesicles shed from cancer cells contain a number ...
... involved in shedding of cell surface molecules, development, inflammation, and release of signaling molecules. Memapsin 2 and presenilins are associated with Alzheimer's disease. Membrane vesicles shed from cancer cells contain a number ...
Стр. xix
... involved in cleaving numerous extracellular matrix proteins (Chapters 1–10 and 14); they are also involved in processing peptide substrates including growth factors, cytokines, chemokines, hormones, and angiogenic factors (Chapters 1, 3 ...
... involved in cleaving numerous extracellular matrix proteins (Chapters 1–10 and 14); they are also involved in processing peptide substrates including growth factors, cytokines, chemokines, hormones, and angiogenic factors (Chapters 1, 3 ...
Стр. xxi
... involved in various cell functions (see Chapter 3). Another mechanism that cells have evolved to enhance protease ... involvement of multiple cell surface proteases represents an area of exciting new development, as represented by ...
... involved in various cell functions (see Chapter 3). Another mechanism that cells have evolved to enhance protease ... involvement of multiple cell surface proteases represents an area of exciting new development, as represented by ...
Содержание
75 | |
Chapter 3 Biochemical Properties and Functions of MembraneAnchored MetalloproteaseDisintegrin Proteins ADAMs | 101 |
Chapter 4 Shedding of Plasma Membrane Proteins | 125 |
Chapter 5 Expression of Meprins in Health and Disease | 145 |
Chapter 6 Type II Transmembrane Serine Proteases | 167 |
Chapter 7 DPPIV Seprase and Related Serine Peptidases in Multiple Cellular Functions | 207 |
Chapter 8 The Secretases of Alzheimers Disease | 233 |
Chapter 9 Plasminogen Activation at the Cell Surface | 263 |
Understanding Its Functional Significance | 313 |
Chapter 11 ProteaseActivated Receptors | 343 |
Chapter 12 Emmprin CD147 a Cell Surface Regulator of Matrix Metalloproteinase Production and Function | 371 |
Implications for Developmental Adaptive Inflammatory and Neoplastic Processes | 391 |
Chapter 14 Shed Membrane Vesicles and Clustering of MembraneBound Proteolytic Enzymes | 411 |
Index | 433 |
Contents of Previous Volumes | 447 |
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Часто встречающиеся слова и выражения
Acad ADAMs adhesion amino acid amyloid angiogenesis astacin binding Biochem breast C-terminal cancer cells Cancer Res carcinoma cells catalytic domain cathepsin cDNA Cell Biol cell lines cell migration cell surface cellular Chem chemokines cleavage cleaved Cloning collagen collagenase complex corin cytoplasmic degradation disease DPPIV emmprin endothelial cells enteropeptidase enzyme expression extracellular matrix fibroblasts fibronectin function gelatinase gene growth factor hepsin human induced inhibition inhibitors integrin interactions invasion involved kinase ligand lysosomes matriptase matrix metalloproteinase mechanism mediated membrane-type meprin metastasis mice MMPs module molecular molecules mouse mRNA MT1-MMP mutations Natl overexpression PAR1 peptidase peptide plasma membrane plasmin plasminogen activation system plasminogen activator platelet potential presenilin processing proMMP-2 protein proteolysis proteolytic receptor regulation residues role secreted Seiki seprase sequence serine protease signaling soluble specific structure substrate subunit TACE thrombin tissue transmembrane tumor tumor cells uPAR urokinase vascular vesicles shed vitro vivo
Популярные отрывки
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Стр. 254 - JJ, et al. (1992) Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the beta-amyloid precursor protein gene.
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Стр. 252 - Borchelt, DR, Thinakaran, G., Eckman, CB, Lee, MK, Davenport, F., Ratovitsky, T., Prada, CM, Kim, G., Seekins, S., Yager, D., Slunt, HH, Wang, R., Seeger, M., Levey, AI, Gandy, SE, Copeland, NG, Jenkins, NA, Price, DL, Younkin, SG, Sisodia, SS (1996) Familial Alzheimer's disease-linked presenilin 1 variants elevate Aft 1-42/1 -40 ratio in vitro and in vivo.
Стр. 94 - H-ras oncogene-transformed human bronchial epithelial cells (TBE-1) secrete a single metalloprotease capable of degrading basement membrane collagen. J. Biol. Chem., 263, 6579-6587.
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