Cell Surface ProteasesElsevier, 3 мая 2003 г. - Всего страниц: 452 Cell Surface Proteases provides a comprehensive overview of these important enzymes that catalyze the hydrolysis of a protein as it degrades to a simpler substance. In the 1990s, an explosion of new discoveries shed light on the role of cell surface proteases and extended it beyond degradation of extracellular matrix components to include its influence on growth factors, cell signaling, and other cellular events. This volume unites the scientific literature from across disciplines and teases out unified themes of interactions between cell surface proteases and interconnecting cell surface-related systems -- including integrins and other adhesion molecules. Scientists and students involved in developmental biology, cell biology and disease processes will find this an indispensable resource. * Provides an overview of the entire field of cell surface proteases in a single volume* Presents major issues and astonishing discoveries at the forefront of modern developmental biology and developmental medicine * A thematic volume in the longest-running forum for contemporary issues in developmental biology with over 30 years of coverage |
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Стр. 11
... mutations in this conserved region have been shown to be detrimental for MT1-MMP function in terms of activation of proMMP-2, binding of TIMP-2 to the cell surface, cell migration, and substrate degradation. Therefore, this four-residue ...
... mutations in this conserved region have been shown to be detrimental for MT1-MMP function in terms of activation of proMMP-2, binding of TIMP-2 to the cell surface, cell migration, and substrate degradation. Therefore, this four-residue ...
Стр. 13
... mutation nor deletion of this region significantly impaired the catalytic activity of this enzyme toward synthetic peptides or fibrinogen (English et al., 2001a). Therefore, these residues appear to have little influence on the ...
... mutation nor deletion of this region significantly impaired the catalytic activity of this enzyme toward synthetic peptides or fibrinogen (English et al., 2001a). Therefore, these residues appear to have little influence on the ...
Стр. 15
... mutation in a cysteine residue in the C-terminal domain of MT1-MMP has been reported to interfere with cell migration and invasion, possible by abolishing formation of MT1-MMP dimers (Rozanov et al., 2001). However, other studies ...
... mutation in a cysteine residue in the C-terminal domain of MT1-MMP has been reported to interfere with cell migration and invasion, possible by abolishing formation of MT1-MMP dimers (Rozanov et al., 2001). However, other studies ...
Стр. 40
... mutations were identified. The nonsense mutation effects a deletion of the substrate binding domain and catalytic sites of the fibronectin type II-like and hemopexin/TIMP-2 binding domains. Martignetti et al. (2001) pointed out that the ...
... mutations were identified. The nonsense mutation effects a deletion of the substrate binding domain and catalytic sites of the fibronectin type II-like and hemopexin/TIMP-2 binding domains. Martignetti et al. (2001) pointed out that the ...
Содержание
75 | |
Chapter 3 Biochemical Properties and Functions of MembraneAnchored MetalloproteaseDisintegrin Proteins ADAMs | 101 |
Chapter 4 Shedding of Plasma Membrane Proteins | 125 |
Chapter 5 Expression of Meprins in Health and Disease | 145 |
Chapter 6 Type II Transmembrane Serine Proteases | 167 |
Chapter 7 DPPIV Seprase and Related Serine Peptidases in Multiple Cellular Functions | 207 |
Chapter 8 The Secretases of Alzheimers Disease | 233 |
Chapter 9 Plasminogen Activation at the Cell Surface | 263 |
Understanding Its Functional Significance | 313 |
Chapter 11 ProteaseActivated Receptors | 343 |
Chapter 12 Emmprin CD147 a Cell Surface Regulator of Matrix Metalloproteinase Production and Function | 371 |
Implications for Developmental Adaptive Inflammatory and Neoplastic Processes | 391 |
Chapter 14 Shed Membrane Vesicles and Clustering of MembraneBound Proteolytic Enzymes | 411 |
Index | 433 |
Contents of Previous Volumes | 447 |
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Часто встречающиеся слова и выражения
Acad ADAMs adhesion amino acid amyloid angiogenesis astacin binding Biochem breast C-terminal cancer cells Cancer Res carcinoma cells catalytic domain cathepsin cDNA Cell Biol cell lines cell migration cell surface cellular Chem chemokines cleavage cleaved Cloning collagen collagenase complex corin cytoplasmic degradation disease DPPIV emmprin endothelial cells enteropeptidase enzyme expression extracellular matrix fibroblasts fibronectin function gelatinase gene growth factor hepsin human induced inhibition inhibitors integrin interactions invasion involved kinase ligand lysosomes matriptase matrix metalloproteinase mechanism mediated membrane-type meprin metastasis mice MMPs module molecular molecules mouse mRNA MT1-MMP mutations Natl overexpression PAR1 peptidase peptide plasma membrane plasmin plasminogen activation system plasminogen activator platelet potential presenilin processing proMMP-2 protein proteolysis proteolytic receptor regulation residues role secreted Seiki seprase sequence serine protease signaling soluble specific structure substrate subunit TACE thrombin tissue transmembrane tumor tumor cells uPAR urokinase vascular vesicles shed vitro vivo
Популярные отрывки
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