Protein Degradation in Health and Disease, Часть 3Michèle Reboud-Ravaux Springer Science & Business Media, 2002 - Всего страниц: 130 Protein degradation has been identified as a major mechanism for the regulation of cellular functions. Not surprisingly, its deregulation is implied in almost any pathological condition. This book describes how aged proteins are eliminated during cell metabolism, how cell proliferation is regulated by protein degradation and how its deregulation can contribute to the development of cancer, how protein degradation is modified during normal and abnormal aging, in particular with regard to Alzheimer's disease and other degenerative diseases of the brain and central nervous system. Attempts aiming at correcting these pathologies by interfering with deviations of the normal pathway of protein degradation are also treated. |
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198 complex 26S proteasome a-synuclein Acad Sci USA accumulation age-related aging Alzheimer's disease amino acids amyloid Annu Rev ATPases Baumeister binding Biochem Biophys Biol Chem brain C-terminal calpain catalytic Cell Biol cell cycle chain chaperones Ciechanover Conconi conjugated Coux cyclin damaged proteins deubiquitinating enzyme EMBO enzyme eukaryotic F-box proteins filaments Friguet function Genes Dev Goedert Goldberg Groll Hershko Hippel-Lindau Hochstrasser inhibit interaction intracellular protein kinase lactacystin Lewy bodies liver lysosomal mechanisms mediated membrane MHC class Mol Cell molecular molecules multicatalytic proteinase mutant N-end rule Natl Acad Sci NEDD8 neurodegenerative neuronal oxidative stress oxidized protein peptidase activities peptides phosphorylation poly-ubiquitin presenilin prion Proc Natl Acad protease proteasomal system proteasome activity proteasome complex proteasome inhibitors protein degradation proteolysis receptor regulation regulatory residues rings role SCF complex specific Stadtman structure substrate subunits Tanaka target proteins teasome tion trypsin-like tumor suppressor ubiquitin ligase ubiquitin-proteasome pathway ubiquitylation viral yeast