Mechanisms of MemoryElsevier, 18 нояб. 2003 г. - Всего страниц: 350 This book stands as the first unified overview of the cellular and molecular mechanisms underlying higher-order learning and memory. It integrates modern discoveries concerning learning and memory disorders such as mental retardation syndromes and Alzheimer's Disease, while also emphasizing the results gained from the cutting-edge research methodologies of genetic engineering, complex behavioral characterization, proteomics, and molecular biology. This book provides a foundation of experimental design that will be useful to all students pursuing an interest in laboratory research. This book is an enlightening and invaluable resource for anyone concerned with memory mechanisms. * Presents a unified view of memory mechanisms from behavior to genes and drawing examples from many different brain regions, types of learning, and various animal model systems * Includes numerous practical examples for the new investigator on how to implement research program in the area of learning and memory * Provides a balanced treatment of the strengths and weaknesses in modern experimental design |
Содержание
| 3 | |
| 29 | |
| 61 | |
Chapter 4 LongTerm Potentiation as a Physiological Phenomenon | 91 |
Chapter 5 Complexities of LongTerm Potentiation | 117 |
Chapter 6 The Biochemistry of LTP Induction | 147 |
Chapter 7 Biochemical Mechanisms for ShortTerm Information Storage at the Cellular Level | 189 |
Chapter 8 Biochemical Mechanisms for LongTerm Information Storage at the Cellular Level | 233 |
Chapter 9 LTP Does Not Equal Memory | 263 |
Chapter 10 Inherited Disorders of Human MemoryMental Retardation Syndromes | 307 |
Chapter 11 AgingRelated Memory Disorders Alzheimers Disease | 337 |
Chapter 12 The Chemistry of Perpetual Memory | 367 |
Index | 391 |
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Часто встречающиеся слова и выражения
action potential activity-dependent altered Alzheimer’s disease AMPA amyloid animal animal’s Aplysia area CA1 associated autophosphorylation BDNF behavioral binding biochemical block brain calmodulin CaMKII cascade cellular changes channels chapter complex component context cortex CREB cues deficits dendritic dentate gyrus depolarization discussed E-LTP enzyme EPSP ERK activation example experiments fear conditioning Figure firing foot shock gene expression glutamate hippocampal hippocampal slices hippocampus-dependent hypothesis increased inhibition inhibitor inputs involved Kandel knockout L-LTP learning and memory long-lasting long-term memory long-term potentiation LTP induction maze mechanisms membrane memory consolidation memory formation mental retardation mice modulation molecular molecules mRNA mutations Neurosci neurotransmitter NMDA receptor-dependent paradigm pathway peptide persisting phosphorylation place cell postsynaptic presynaptic processes protein kinase protein synthesis pyramidal neurons reference regulation response role sensory neurons signal transduction spatial learning specific spine stimulation studies subunits Sweatt synaptic plasticity synaptic transmission Syndrome target tion transgenic triggering types
Популярные отрывки
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Стр. 389 - When an axon of cell A is near enough to excite a cell B and repeatedly or persistently takes part in firing it, some growth process or metabolic change takes place in one or both cells such that A's efficiency, as one of the cells firing B, is increased.
Стр. 364 - Morgan, D., Diamond, DM, Gottschall, PE, Ugen, KE, Dickey, C., Hardy, J., Duff, K., Jantzen. P., DiCarlo, G., Wilcock, D., Connor, K., Hatcher, J., Hope, C.. Gordon, M., and Arendash, GW, A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease, Nature, 408, 982, 2000.
Стр. 363 - Linkage of plasma Abeta42 to a quantitative locus on chromosome 10 in late-onset Alzheimer's disease pedigrees.
Стр. 361 - DL (1990) Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport.
Ссылки на эту книгу
Science of Memory: Concepts Henry L. Roediger III,Yadin Dudai,Susan M. Fitzpatrick Ограниченный просмотр - 2007 |