Molecular Biology of Alzheimer's Disease: Genes and Mechanisms Involved in Amyloid Generation

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Christian Haass
CRC Press, 2 сент. 2003 г. - Всего страниц: 330
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Highlighting the latest and the most timely aspects of Alzheimer's disease research, this text will enable scientists in related research fields, as well as physicians working with Alzheimer's disease patients, to obtain a quick and complete overview of the current state of the art in one of the most exciting fields in neuroscience research. Leading scientists have contributed articles focusing on key developments in this field. This includes an overview about the pathology, the genetics of familial Alzheimer's disease, proteolytic generation and aggregation of amyloid -peptide, presenilins, risk factors such as ApoE, and transgenic animal models. Some of the latest developments in Alzheimer's disease research, including the effect of presenilin knock outs on amyloid -peptide generation, are also included.

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THE GENETICS OF FAMILIAL ALZHEIMERS DISEASE
43
MOLECULAR AND CELLULAR BIOLOGY OF THE BAMYLOID PRECURSOR PROTEIN AND AMYLOID BPEPTIDE
69
THE PRESENILIN GENES
184
ROLE OF RISK FACTORS IN ALZHEIMERS DISEASE
280
TRANSGENIC MODELS FOR ALZHEIMERS DISEASE
297
INDEX
321
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