Proteases as Targets for Therapy, Выпуск 146Klaus von der Helm, Bruce D. Korant, John Chris Dion Cheronis Springer Science & Business Media, 2000 - Всего страниц: 410 Section I. Human Immunodeficiency Virus Protease Inhibitors.- 1 The Road to Fortovase. A History of Saquinavir, the First Human Immunodeficiency Virus Protease Inhibitor.- 2 Clinical Experience with Human Immunodeficiency Virus Protease Inhibitors: Antiretroviral Results, Questions and Future Strategies.- 3 The Nature of Resistance to Human Immunodeficiency Virus Type-1 Protease Inhibitors.- 4 The Next Generation of Human Immunodeficiency Virus Protease Inhibitors: Targeting Viral Resistance.- Section II. Other Viral (Non-HIV) Protease Inhibitors.- 5 The Proteinases Encoded by Hepatitis C Virus as Therapeutic Targets.- 6 The Human Herpes-Virus Proteases.- 7 The 3C Proteinases of Picornaviruses and Other Positive-Sense, Single-Stranded RNA Viruses.- 8 Adenovirus Proteinase-Antiviral Target for Triple-Combination Therapy on a Single Enzyme: Potential Inhibitor-Binding Sites.- 9 Proteinases as Virulence Factors in Bacterial Diseases and as Potential Targets for Therapeutic Intervention with Proteinase Inhibitors.- 10 Parasite Proteases as Targets for Therapy.- Section III. (Non-Viral) Proteases Involved in Diseases.- 11 Host Proteinases as Targets for Therapeutic Intervention.- 12 The Role of Metalloprotease Inhibitors in Cancer and Chronic Inflammatory Diseases.- 13 The Tumor Necrosis Factor-? Converting Enzyme.- 14 Serine Elastases in Inflammatory and Vascular Diseases.- 15 Inhibitors of Thrombin and Factor Xa.- 16 Inhibitors of Papain-Like Cysteine Peptidases in Cancer.- 17 Caspases and Their Natural Inhibitors as Therapeutic Targets for Regulating Apoptosis.- 18 Proteasome and Apoptosis.- 19 Proteolytic Processing of the Amyloid Precursor Protein of Alzheimer's Disease.- 20 Presenilins and ?-Amyloid Precursor Protein-Proteolytically Processed Proteins Involved in the Generation of Alzheimer's Amyloid ? Peptide. |
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... Apoptosis Q.L. DEVERAUX , J.C. REED , and G.S. SALVESEN . With 3 Figures 329 A. Apoptosis 329 B. Apoptosis Is Mediated by Caspase D. Sturctural Characteristics of the IAPS E. Biology of the Human IAPS . F. IAPS as Therapeutic Targets G ...
... Apoptosis Q.L. DEVERAUX , J.C. REED , and G.S. SALVESEN . With 3 Figures 329 A. Apoptosis 329 B. Apoptosis Is Mediated by Caspase D. Sturctural Characteristics of the IAPS E. Biology of the Human IAPS . F. IAPS as Therapeutic Targets G ...
Стр. xxvii
... Apoptosis E. Proteasome Inhibitors Help Elucidate the Biological Roles of the Proteasome in the Apoptotic Pathway .. 346 F. The Ub - Proteasome System and Cancer Therapy G. Perspectives References CHAPTER 19 Proteolytic Processing of ...
... Apoptosis E. Proteasome Inhibitors Help Elucidate the Biological Roles of the Proteasome in the Apoptotic Pathway .. 346 F. The Ub - Proteasome System and Cancer Therapy G. Perspectives References CHAPTER 19 Proteolytic Processing of ...
Стр. 213
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Стр. 235
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Стр. 330
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Содержание
TANAKA K The Tokyo Metropolitan Institute of Medical Science | 3 |
Early Clinical Studies | 13 |
3333 | 20 |
Clinical Experience with Human Immunodeficiency Virus Protease | 23 |
CHAPTER 3 | 33 |
Different Classes of Resistance Mutations in the Protease | 39 |
CHAPTER 4 | 49 |
Suggestions for Future Therapeutic Strategies | 66 |
General Considerations in the Development of MMPIS | 224 |
G Conclusions | 231 |
Inhibitors of TACE and TNFa Secretion | 245 |
CHAPTER 14 | 259 |
B Serine Elastases and Inflammation | 262 |
Potential Clinical Targets for SerineElastase Inhibition | 268 |
82 | 273 |
CHAPTER 15 | 277 |
CHAPTER 5 | 75 |
The NS23 Proteinase | 87 |
CHAPTER 6 | 95 |
78 | 101 |
E CellBased Activity of Protease Inhibitors | 108 |
CHAPTER 7 | 117 |
E The 3C Proteinases | 125 |
F Inhibition of 3C Proteinases | 132 |
CHAPTER 8 | 145 |
Potential InhibitorBinding Sites | 152 |
E Summary and Prospects | 155 |
80 | 165 |
E Paradigms for Testing Proteinase Inhibitors as Therapeutic | 173 |
F Bacterial Proteinases to the Rescue | 179 |
CHAPTER 10 | 189 |
Serine Proteases | 198 |
CHAPTER 11 | 207 |
Section Overview | 213 |
81 | 218 |
CHAPTER 12 | 221 |
FactorXa Inhibitors | 289 |
83 | 295 |
118 | 297 |
CHAPTER 16 | 301 |
Cystatins in Cancer | 310 |
Potential Transcriptional Regulation | 316 |
84 | 324 |
CHAPTER 17 | 329 |
G Potential for Caspase Inhibitor Therapy | 335 |
CHAPTER 18 | 341 |
Regulatory Control of Ub and the Proteasome in Apoptosis | 346 |
F The UbProteasome System and Cancer Therapy | 353 |
CHAPTER 19 | 359 |
87 | 370 |
Role of Mutant Presenilins in Amyloid Generation | 378 |
E Proteolytic Degradation of PSs | 384 |
390 | |
403 | |
404 | |
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Proteases as Targets for Therapy Klaus, von der Helm,Bruce D. Korant,John C. Cheronis Ограниченный просмотр - 2012 |
Proteases as Targets for Therapy Klaus, von der Helm,BRUCE KORANT,John C. Cheronis Недоступно для просмотра - 2012 |
Часто встречающиеся слова и выражения
3C proteinases active-site adenovirus agents amino acids anticoagulant antithrombin antiviral apoptosis apoptotic bacterial Barrett batimastat binding Biochem Biol Chem cancer caspase catalytic cathepsin cathepsin G cell death cleavage cleaved Clin clinical collagenase complex compounds cystatin cysteine peptidases cysteine proteinase cytokines degradation disease domain drug effects elastase extracellular factor Xa function gene gingipains gingivalis Handbook of proteolytic heparin hirudin HIV protease IAPS identified inactivation indinavir induced inflammatory inhibition interactions kininogens marimastat matrix metalloproteinase membrane mice molecular molecules mutations Natl Acad Sci neutrophil papain parasite pathogens pathway patients peptidases peptide platelet polyprotein potential precursor Proc Natl Acad processing protease inhibitors proteasome protein proteolytic enzymes pVIc Rawlings ND receptor residues resistance ritonavir role saquinavir sequence serine proteinase specific stefin studies substrate TACE target teinase therapeutic therapy tion tissue tumor necrosis ubiquitination viral Virol viruses vitro vivo Woessner JE eds y-secretase
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