Science, Том 317,Выпуски 5834-5840John Michels (Journalist) American Association for the Advancement of Science, 2007 |
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... PDZ domains ( fig . S1 ) . Whereas previous efforts to characterize the selectivity of PDZ domains have relied on collections of pep- tides with randomized sequences ( 7 , 9 , 13 , 14 ) , our goal was to focus on genome - encoded se ...
... PDZ domains ( fig . S1 ) . Whereas previous efforts to characterize the selectivity of PDZ domains have relied on collections of pep- tides with randomized sequences ( 7 , 9 , 13 , 14 ) , our goal was to focus on genome - encoded se ...
Стр. 366
... domains , we developed a variation of a PSSM in which a peptide is predicted to bind to PDZ domain i if ❤i = Σ Ap ... PDZ domain selectivity , we constrained Σε to be 0 for every position p and every amino acid q . Thus , Op.q is ...
... domains , we developed a variation of a PSSM in which a peptide is predicted to bind to PDZ domain i if ❤i = Σ Ap ... PDZ domain selectivity , we constrained Σε to be 0 for every position p and every amino acid q . Thus , Op.q is ...
Стр. 368
... domains PDZ - RGS3 ( 1/1 ) and Grip1 ( 6/7 ) lie at the positive end . Erbin ( 1/1 ) , which has been shown to bind both class I and class II peptides ( 28-31 ) , lies between the two extremes . The second and third principal axes ( Fig ...
... domains PDZ - RGS3 ( 1/1 ) and Grip1 ( 6/7 ) lie at the positive end . Erbin ( 1/1 ) , which has been shown to bind both class I and class II peptides ( 28-31 ) , lies between the two extremes . The second and third principal axes ( Fig ...
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