Science, Том 317,Выпуски 5834-5840John Michels (Journalist) American Association for the Advancement of Science, 2007 |
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Стр. 206
... ( PI3K ) signaling pathway is crucial to the via- bility of many cancers ( 1-3 ) . PI3K inhibitors block cancer cell growth and sur- vival , and some genetic alterations , such as loss of the PTEN tumor suppressor , increase PI3K activity ...
... ( PI3K ) signaling pathway is crucial to the via- bility of many cancers ( 1-3 ) . PI3K inhibitors block cancer cell growth and sur- vival , and some genetic alterations , such as loss of the PTEN tumor suppressor , increase PI3K activity ...
Стр. 207
... PI3K . The major stabilizing interaction in PI3K involves the p85 iSH2 and p110a ABD domains . Inhibition of PI3K is mediated by a charge - charge interaction ( shown as plus and minus signs ) between the p85 nSH2 domain and the helical ...
... PI3K . The major stabilizing interaction in PI3K involves the p85 iSH2 and p110a ABD domains . Inhibition of PI3K is mediated by a charge - charge interaction ( shown as plus and minus signs ) between the p85 nSH2 domain and the helical ...
Стр. 241
... PI3K activity ( % basal ) 50 100 50 0 p85ni p110α C Relative PI3K activity ( % basal ) + WT E542K E545K Q546K p110g - WT 140 120 100 ៖ ៖ ៖ ៖ ៖ ៖ ៖ 140 120 -p85ni - K379E 100 -p85ni - WT 50 100 150 p85ni ( nM ) ...
... PI3K activity ( % basal ) 50 100 50 0 p85ni p110α C Relative PI3K activity ( % basal ) + WT E542K E545K Q546K p110g - WT 140 120 100 ៖ ៖ ៖ ៖ ៖ ៖ ៖ 140 120 -p85ni - K379E 100 -p85ni - WT 50 100 150 p85ni ( nM ) ...
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