Protein Trafficking in NeuronsAndrew J. Bean Elsevier, 27 окт. 2006 г. - Всего страниц: 464 The efficient delivery of cellular constituents to their proper location is of fundamental importance for all cells and is of particular interest to neuroscientists, because of the unique functions and complex architecture of neurons. Protein Trafficking in Neurons examines mechanisms of protein trafficking and the role of trafficking in neuronal functioning from development to plasticity to disease. The book is divided into seven sections that review mechanisms of protein transport, the role of protein trafficking in synapse formation, exo- and endocytosis, transport of receptors, trafficking of ion channels and transporters, comparison of trafficking mechanisms in neuronal vs. non-neuronal cell types, and the relationship between trafficking and neuronal diseases such as Alzheimer's, Huntington's and Prion Diseases.
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Содержание
| 61 | |
EXOENDOCYTOSIS | 95 |
RECEPTOR TRAFFICKING | 141 |
TRAFFICKING OF ION CHANNELS AND TRANSPORTERS | 223 |
TRAFFICKING IN OTHER CELL TYPES | 269 |
PROTEIN TRAFFICKING AND NEURONAL DISEASE | 367 |
Index | 437 |
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Acad acid actin active zone adaptor AMPA receptors apical astrocytes axon basolateral binding brain brane Ca2+ calcium Cell Biol cell surface cellular Chem cholesterol chromaffin clathrin clustering complex cytoplasmic cytoskeleton dendritic spines diffusion disease domain Drosophila dynamics dynein Ehlers endocytic endocytosis epithelial cells excitatory Exocyst exocytic exocytosis extrasynaptic fluorescence function fusion pore gene GluR1 GluR2 glutamate receptors Golgi hippocampal hippocampal neurons interactions intracellular kinesin Kv channels late endosomes lipid localization MDCK cells mechanisms mediated membrane proteins mice microtubules molecular molecules motif motor mutant myosin Natl neurite neurons Neurosci neurotransmitter NMDA NMDA-R NR2A NR2B organelles pathway PC12 cells phosphorylation plasma membrane polarized postsynaptic presynaptic Proc protein kinase recep receptor subunits receptor trafficking recycling regulated role secretory signaling SNARE sorting studies Sudhof surface expression synaptic transmission synaptic vesicle synaptotagmin syntaxin targeting tion trans transport vesicular VGLUTs VMAT2 Wang
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