Research Progress in Alzheimer's Disease and Dementia, Том 2Nova Publishers, 2007 - Всего страниц: 378 Alzheimer's disease (AD), the most common type of neurodegenerative disorder in the aging population, is characterised pathologically by extracellular amyloid plaques and intracellular neurofibrillary tangles, pathophysiologically by synaptic dysfunction, and clinically by a progressive dementia. The rapid progress in the research fields of AD and dementia continues since the publication of the first book volume with the same title. This second book volume contains 14 chapters, bringing together a presentation of research frontiers in current AD/dementia research. (APP) processing and neurotransmitter and signal molecules involved in regulation of APP processing, transgenic AD mouse models and their relevance to AD research, amyloid -peptide (A) immunisation, cerebral inflammation, myelin breakdown, roles of deregulation of cell cycle in AD pathology, relationship between cholesterol and AD, A binding to cholesterol and cholesterol oxidation, A-binding alcohol dehydrogenase and roles in AD pathogenesis, sex steroids, oestrogen therapy for AD prevention, behavioural and psychological symptoms of AD, memantine for AD therapy, enoxaparin as a therapeutic agent for AD, to molecular links between AD and traumatic brain injury. memory-relevant AD pathogenesis, as shown in these chapters written by world-wide leaders in the fields, are more encouraging. The book will be highly valuable to students and scientists world-wide who are interested in the scientific research progress in AD and dementia. |
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Стр. 29
... allele of the apolipoprotein E gene ( ApoE , located on chromosome 19 ) , in contrast to only 15 % in the normal , healthy population . Since no direct causal links or inheritance patterns are evident , the presence of ApoE4 identifies ...
... allele of the apolipoprotein E gene ( ApoE , located on chromosome 19 ) , in contrast to only 15 % in the normal , healthy population . Since no direct causal links or inheritance patterns are evident , the presence of ApoE4 identifies ...
Стр. 30
... allele ( Corder , et al . , 1993 ) . Interestingly , there is evidence suggesting that its effect might vary amongst different races ( Evans , et al . , 2003 ) . The ApoE - ε4 allele was found to increase the risk of developing AD ...
... allele ( Corder , et al . , 1993 ) . Interestingly , there is evidence suggesting that its effect might vary amongst different races ( Evans , et al . , 2003 ) . The ApoE - ε4 allele was found to increase the risk of developing AD ...
Стр. 33
... alleles expressed at equal ( or greater ) steady - state levels . ( This is not to exclude the possibility that , using the precedent of APP gene triplication in Down's syndrome , overexpression of wtAPP might also be enlightening as to ...
... alleles expressed at equal ( or greater ) steady - state levels . ( This is not to exclude the possibility that , using the precedent of APP gene triplication in Down's syndrome , overexpression of wtAPP might also be enlightening as to ...
Стр. 46
... allele and the risk of Alzheimer's disease in late onset families . Science 261 , 921- 3 , 1993 . Cork , L.C. , Powers , R.E. , Selkoe , D.J. , Davies , P. , Geyer , J.J. and Price , D.L. Neurofibrillary tangles and senile plaques in ...
... allele and the risk of Alzheimer's disease in late onset families . Science 261 , 921- 3 , 1993 . Cork , L.C. , Powers , R.E. , Selkoe , D.J. , Davies , P. , Geyer , J.J. and Price , D.L. Neurofibrillary tangles and senile plaques in ...
Стр. 47
... allele status . Arch Neurol 60 , 185-9 , 2003 . Evans , D.A. , Funkenstein , H.H. , Albert , M.S. , Scherr , P.A. , Cook , N.R. , Chown , M.J. , Hebert , L.E. , Hennekens , C.H. and Taylor , J.O. Prevalence of Alzheimer's disease in a ...
... allele status . Arch Neurol 60 , 185-9 , 2003 . Evans , D.A. , Funkenstein , H.H. , Albert , M.S. , Scherr , P.A. , Cook , N.R. , Chown , M.J. , Hebert , L.E. , Hennekens , C.H. and Taylor , J.O. Prevalence of Alzheimer's disease in a ...
Содержание
1 | |
27 | |
57 | |
Myelin Breakdown Trajectories and Risk Factors for AgeRelated Cognitive Decline and Alzheimers Disease | 97 |
Alzheimers Disease A Deregulated Cell Cycle Disease | 109 |
Cholesterol Statins and Alzheimers Disease Past Present and Future | 123 |
Cholesterol Oxidation and PAmyloid Perspectives on Alzheimers Disease and Therapy | 137 |
ABAD Mitochondrial Target for APMediated Cellular Perturbation in Alzheimers Disease | 175 |
The Role of Sex Steroids in Alzheimers Disease and AgeRelated Cognitive Decline | 191 |
Estrogen Therapy for Preventing Alzheimers Disease Therapeutic Strategies to Address Hormone Therapy Challenge for the Brain | 227 |
Behavioral and Psychological Symptoms of Alzheimers Disease | 251 |
Memantine for Alzheimers Disease | 273 |
Enoxaparin as a Therapeutic Agent for Alzheimers Disease | 307 |
Head Injury and Dementia | 327 |
Index | 357 |
Часто встречающиеся слова и выражения
a-secretase ABAD Abeta activation age-related agonist allele Alzheimer's disease amyloid beta amyloid precursor protein amyloid-beta antibody ApoE apolipoprotein apoptosis Aẞ deposition associated astrocytes Bartzokis behavioral beta beta-amyloid binding Biol Chem BPSD Brain Res cell cycle cerebral cholesterol clinical cognitive decline cognitive function cognitive impairment complement cortex cortical cytokines decreased dementia disorders drugs effects enzyme ERẞ estrogen excitotoxicity expression gene genetic genotype glutamate growth factor heparin hippocampal Hogervorst hormones human immunisation increased induced inflammation inflammatory inhibition inhibitors injury interaction interleukin-6 kinase levels McGeer mechanisms mediated memantine memory menopause metabolism microglia mitochondrial model of Alzheimer's mouse model mRNA mutations myelin Neurobiol Aging Neurochem neurodegenerative neurofibrillary tangles Neurology neurons neuroprotective Neurosci neurotoxicity NMDA receptor overexpressing oxysterols pathology pathway patients peptide placebo potential presenilin production Psychiatry reduced regulation risk factor role ẞ-amyloid statins studies symptoms testosterone therapeutic therapy toxicity transgenic transgenic mice treatment vitro vivo
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