The Prime Function of Nervous Tissue-Subordination to Other Tis- sues-Independence of Nerve Force-Genesis of Nerve Force-Ar- rangement of Nerve Tissue-White and Gray Matter-The Cerebro- Spinal and Sympathetic Systems-The Nerve Cells-The Nerve Fibres -The Neurilemma-The Axis Cylinder-The Gray Fibres-The Prop- erties of Nerves-Terminations of Sensitive Nerves-Terminations of Motor Nerves-Course of Nerve Fibres-Identity of Nerve Fibres -Indifference of Direction of Nerve Force-The Chemistry of Nerve Tissue-The Action of Electricity upon Nerve Tissue-The Nature of Nerve Force-Rate of Conduction of Nerve Force-Nerve Force and Electricity-Comparative Velocity of Nerve and Other Forms of Force-The Reception and Perception of Impressions-Ancient Sig- nificance of Nerves--The Effects of Use and Disuse and of Age.......223-246 The Value of the Blood-The Transfusion of Blood-The Constitu- tion of the Blood-The Color of the Blood-Reaction of the Blood -The Odor of the Blood-The Taste of the Blood-The Temperature of the Blood-The Weight of the Blood-The Quantity of the Blood -The Morphology of the Blood-The Red Blood Corpuscles-Size of the Red Corpuscles-Number of the Red Corpuscles-Elasticity of the Red Corpuscle-Constitution of the Red Corpuscles-Use of the Red Corpuscles-The Colorless Blood Corpuscles-The Blood Plasma-The Coagulation of the Blood-The Blood as the Substitute PRELIMINARY COURSE LECTURES. LECTURE I. THE INFLUENCE OF PHYSIOLOGY UPON PRAC- The Address Introductory to the Course on Physiology at the Medical CONTENTS. Dr. Jacob Primrose-The Exercitatio de Motu Cordis, etc.-Science vs. Nobody in this hall ever heard, I venture to say, of Dr. Thereupon Primrose proceeded to put Harvey down. could solve it to his own satisfaction. Then only did he preach his doctrine. He worked on nine years more. He repeated all his old experiments. He made new ones. He called in all his friends whom he considered competent and secured their confirmation. Then only did he publish it. Harvey was fifty years old, it was in 1628, when he published this first and of all the most brilliant triumph of experimental physiology. It was written in the purest spirit of science, expressed with an accuracy the most rigid and impressed with a modesty all through it in accord with its title. He called it “An Attempt.” It was only a short manuscript, seventy-two pages in all, a fact in itself which put it in wonderful contrast to the gigantic folios of speculation composed at that time. There is a spirit of reverence all through it for the labors of his predecessors, especially for those of Galen. It lies now, the original paper, upon the shelves of the British museum; as to the truths contained in it, what child but knows that its heart beats with pulses of blood. There followed after Harvey in later years the next great man in physiology. This man, a Swiss, Albert Haller by name, said of Harvey: "His name is second only to Hippocrates." "Libellus aureus,” he said of his book. Primrose felt towards Harvey, the keen envy of ignorance and pretense towards solid knowledge and sound truth. He hurried out his book under a high-sounding title in just fourteen days. The same Haller said of it: "It is subtle in cavil, in experiment empty." Harvey never noticed it at all. I would like to use this incident in illustration of the subject of my theme. Had the respective studies of these two men, Primrose and Harvey (I will scarcely be pardoned now SCIENCE VS. PRACTICE. 3 for mentioning their names together), anything to do with their characters as men and physicians. Besides this vindication of the study of physiology I would like to use the opportunity to speak of the influence of physiology upon practical medicine as well as upon the status of the medical practitioner. Science vs. Practice. It may seem strange to the non-professional observer that there could be any possible question as to the general use of physiology. A man would hardly entrust his watch for repair to an operator who was not familiar with its mechanism and the manner of its work when in good working order, but there are those in the profession now, hard as it sounds, just as there were in Harvey's day, who believe, or affect to believe, that scientific investigation unfits a man for practice. John Aubrey, who was at Harvey's funeral and “helpt to carry him into the vault," writes: "I have heard him (Harvey) say, that after his booke of the Circulation of the Blood came out, he fell mightily in his practice, and t’was believed by the vulgar that he was crack-brained; and all the physitians were against his opinion and enoyed him. All his profession would allow him to be an excellent anatomist, but I never heard of any that admired his therapeutique way. I knew several practitioners in this town (London) that would not have given 3d. for one of his bills (prescriptions), and that a man could hardly tell by one of his bills what he did aime at." We shall see shortly how much to be admired was the "therapeutique way" of Harvey's contemporaries. It is meet that we should consider these questions now while we stand on the threshold. If we can become fully convinced of the use of its study we shall enter with more 4 THE FALLACY OF EXPERIENCE. earnest zeal. Nothing so dampens enthusiasm, so hampers progress, as doubt of the utility of the work. I might, if I chose, content myself with merely pointing to the discovery of the circulation, the event which marked a new era in practical medicine. The skeptic must shut his eyes on this discovery before he can discuss the question at all. Is there any disease or accident incident to man in the recognition or treatment of which we do not hold this element in mind like letters of the alphabet in reading the page. Take coarser facts. Could any one diagnosticate the character of a valve disease of the heart without a knowledge of the round of the circulation. Does not the treatment of wounded arteries or diseased, as in aneurism, by placing ligatures on the vessels between the heart and the accident or disease rest upon this established course of the torrent of blood. "The active mind of John Hunter," says Mr. Hodgson, "guided by a deep insight into the powers of the animal economy, substituted for a dangerous and unscientific operation, an improvement founded upon a knowledge of those laws which influence the circulating fluids and absorbent system; and few of his brilliant discoveries have contributed more essentially to the benefit of mankind." But I do not wish to rely for our foundation simply upon the great corner stone. I would rather upon this occasion enter into some details that you may be impressed the more firmly, that rational practice is based on the disclosures of physiology, that you may be convinced that the art of medicine, practice, is, or is fast becoming, but a dependent upon its science, physiology. The Fallacy of Experience. Before any knowledge was possessed of the physiological |