Science, Том 317,Выпуски 5841-5846John Michels (Journalist) American Association for the Advancement of Science, 2007 |
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Стр. 1391
... Desipramine Nortriptyline Desipramine Imipramine A Fluoxetine Nortriptyline 0 10 10 10 [ H ] Leucine Bound / Free 0.10 0.08 0.06 0.04 0.02 10 10 0.00 0.0 0.5 1.0 1.5 2.0 [ H ] Leucine Bound ( nM ) [ Compound ] ( Molar ) B 2.5 Fig . 1 ...
... Desipramine Nortriptyline Desipramine Imipramine A Fluoxetine Nortriptyline 0 10 10 10 [ H ] Leucine Bound / Free 0.10 0.08 0.06 0.04 0.02 10 10 0.00 0.0 0.5 1.0 1.5 2.0 [ H ] Leucine Bound ( nM ) [ Compound ] ( Molar ) B 2.5 Fig . 1 ...
Стр. 1392
... desipramine - binding sites in human SERT , NET , and DAT . ( A ) Desipramine - binding site in the LeuT - desipamine crystal structure . Homology model and electrostatic surface potential of desipramine - binding site in ( B ) hSERT ...
... desipramine - binding sites in human SERT , NET , and DAT . ( A ) Desipramine - binding site in the LeuT - desipamine crystal structure . Homology model and electrostatic surface potential of desipramine - binding site in ( B ) hSERT ...
Стр. 1393
... desipramine - binding site and the inhibition mech- anism of substrate uptake by LeuT were conserved also in the human neurotransmitter transporters . We tested the above two hypotheses by mu- tating key residues at the presumed TCA ...
... desipramine - binding site and the inhibition mech- anism of substrate uptake by LeuT were conserved also in the human neurotransmitter transporters . We tested the above two hypotheses by mu- tating key residues at the presumed TCA ...
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