Signal Transduction and Human DiseaseToren Finkel, J. Silvio Gutkind John Wiley & Sons, 18 июл. 2003 г. - Всего страниц: 488 This book uniquely relates the broad impact of signal transduction research on the understanding and treatment of human disease. There have been significant advances in the area of signaling in disease processes, yet no resource presently connects these advances with understanding of disease processes and applications for novel therapeutics. Given the emphasis on translational research and biological relevance in biotechnology, and, conversely, the importance of molecular approaches for clinical research, it is evident that a single resource bridging signaling research and human disease will be invaluable. |
Содержание
| 1 | |
| 23 | |
3 Molecular Mechanisms of Cancer | 71 |
4 Apoptotic Pathways in Cancer Progression and Treatment | 143 |
5 Molecular and Cellular Aspects of Insulin Resistance Implications for Diabetes | 171 |
6 Dysfunction of G ProteinRegulated Pathways and Endocrine Diseases | 201 |
7 Bacterial Regulation of the Cytoskeleton | 233 |
8 Bacterial Toxins and Diarrhea | 259 |
9 Molecular Basis of Severe Combined Immunodeficiency Lessons from Cytokine Signaling Pathways | 279 |
10 Mast CellRelated Diseases Genetics Signaling Pathways and Novel Therapies | 307 |
11 Rheumatology and Signal Transduction | 357 |
12 Molecular Mechanisms of Neurodegenerative Disorders | 377 |
13 Neurotrophic Signaling in Mood Disorders | 411 |
14 Inhibiting Signaling Pathways Through Rational Drug Design | 447 |
Index | 459 |
Другие издания - Просмотреть все
Часто встречающиеся слова и выражения
a-synuclein Acad Sci USA acid actin ADP-ribosylation ADP-ribosylation factor aggregates airway allergic apoptosis Arp2/3 complex associated asthma atopic binding Biochem Biol Chem cancer Carney complex cascade caspase Cell Biol cell cycle cellular Clin clinical cyclin cytokine cytoplasm diabetes disease domain downstream drugs effector effects enzyme expression function G protein gene genetic GPCRs growth factor human IkBa IKKb immune Immunol inactivation increased induced inflammation inhibit inhibitors insulin resistance insulin signaling interaction interleukin intracellular Jak3 levels ligand MAPK mast cells mastocytosis mechanisms mediated membrane mice mitochondrial Mol Cell molecular molecules mutations Natl Acad Sci neurons NF-kB NF-kB activation nuclear Oncogene overexpression oxide patients phosphorylation Proc Natl Acad protein kinase regulation response Rho GTPases role RTKs Salmonella signal transduction signaling pathways specific stimulation studies substrate subunit target TGF-b therapy tion tissue TNF-a toxin transcription factor translocation tumor tyrosine kinase ubiquitin vitro