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peroxisomes and, 168

sites for actions of alcohol, 88-89
Lipoproteins, 155

Liquor liability laws, 283-285
Liver

acetaldehyde metabolism, 152

alcohol dehydrogenase subunits, 149–150

alcohol metabolism, 148–150

Liver injury. See also Cirrhosis

acetaldehyde role, 169–170

alcohol consumption and, 165-166
antioxidant protective mechanism

impairment, 168-169

cognitive deficits, 184

cytokine production and, 169
factors, 165-167, 185

free radicals role, 167–168
gender differences, 166
high-fat diet and, 166-167
hormones and, 167

hypoxia hypothesis, 166, 171
immunologic mechanisms, 170

mortality rates in Western countries, 166–167
neutrophils and, 170-171

nutritional deficiencies and, 166
oxygen deficiency and, 171
treatment options, 171
types, 165

Liver transplantation, 171, 185
Long-sleep mice, 68, 70
Lorazepam, 333

Low-alcohol-drinking rats, 117
Low-alcohol-sensitive rats, 68
Low birth weight, 208-209

Low-density lipoproteins, 155, 172

LST. See Life Skills Training prevention program

Luteinizing hormone, 178, 179, 217

Lymphocytes, 175–176

Lymphokine-activated killer cells, 177

M

m-AspAT. See Mitochondria aspartate

aminotransferase

Magnetic resonance imaging, 85, 101, 180
Major depression

addiction treatment patients and, 42
comorbidity data, 46

course of alcoholism and, 48-49

family studies of comorbidity, 45

MAO. See Monoamine oxidase

MAOIS. See Monoamine oxidase inhibitors
Marijuana

adolescents' use of, 134, 338

condom use and, 245

expectancies about effects, 134

use during pregnancy, 208, 212
Marital therapy, 330

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