Functional neurobiology of aging
Some well-known age-related neurological diseases include Parkinson's disease, Alzheimer's disease, deafness, and blindness. Even more common are the problems of aging which are not due to disease but to more subtle impairments in neurobiological systems, including impairments in vision, memory loss, muscle weakening, and loss of reproductive functions, changes in body weight, and sleeplessness. As the average age of our society increases, diseases of aging continue to become more common, and conditions associated with aging need more attention by doctors and researchers. In 1991, patients over the age of 65 saw their doctors an average of eight times per year. Research funding is provided by the Neuroscience and Neuropsychology of Aging (NNA) Program, which is run by the National Institute on Aging. This book offers a comprehensive overview of all topics related to functional impairments which are related to the aging brain and nervous system. It is organized according to four general functions: movement, senses, memory, and neuroendocrine regulation. Written by the leading researchers in the field, this comprehensive work addresses both impairments associated with diseases and not associated with diseases, making it easier to understand the mechanisms involved. Functional Neurobiology of Aging is an important reference for professionals and students involved in aging research, as well as physicians who need to recognize and understand age-related impairments. Key Features * Organized by function, making it easy to find and understand the material * Addresses impairments both associated with diseases and not associated with diseases * Written by leading researchers in the field * Most comprehensive source of information on the neurobiology of aging
Internet Resources
1 online resource (xxvii, 960 pages) : illustrations (some color)
9780080525587, 008052558X
162572768
Contributors
Foreword
Preface
Overview:
Introduction to Concepts in Aging Research:
Age-Specific Rates of Neurological Disease, J.E. Riggs
Nature versus Nurture in the Aging Brain, C.V. Mobbs and J.W. Rowe
Neurochemistry of Receptor Dynamics in the Aging Brain, B.J. Keck and J.M. Lakoski
Epidemiology of Neural Aging:
Demography and Epidemiology of Age-Associated Neuronal Impairment, C.K. Cassel and K. Ek
Memory: Neocortical and Hippocampal Functions:
Neuropsychology of Human Aging
Memory Changes with Aging and Dementia, P.D. Harvey and R.C. Mohs
Histology of Age-Related Cortical Changes in Humans:
Types of Age-Related Brain Lesions and Relationship to Neuropathological Diagnostic Systems of Alzheimer's Disease, P. Giannakopoulos, E. Kövari, G. Gold, P.R. Hof, and C. Bouras
Morphological changes in Human Cerebral Cortex during Normal Aging, T. Bussière and P.R. Hof
Longevity and Brain Aging: The Paradigm of Centenarians, C. Bouras, P.G. Vallet, E. Kövari, J.-P. Michel, F.R. Herrmann, P.R. Hof, and P. Giannakopoulos
Alzheimer's Disease:
Regional and Laminar Patterns of Selective Neuronal Vulnerability in Alzheimer's Disease, P.R. Hof
Patterns of Cortical Neurodegeneration in Alzheimer's Disease: Subgroups, Subtypes, and Implications for Staging Strategies, B.A. Vogt, L.J. Vogt, and P.R. Hof
Non-Alzheimer Age-Associated Dementing Disorders:
Vascular Dementia, G. Gold, C. Bouras, J.-P. Michel, P.R. Hof, and P. Giannakopoulos
Frontotemporal Dementias: From Classification Problems to Pathogenetic Uncertainties, P. Giannakopoulos, E. Kövari, G. Gold, P.R. Hof and C. Bouras
Progressive Supranuclear Palsy and Corticobasal Degeneration, D.W. Dickson
Neurobiology of Disorders with Lewy Bodies, L. Hansen and E. Masliah
Amyotrophic Lateral Sclerosis/Parkinsonism-Dementia Complex of Guam, D.P. Perl
In Vivo Imaging of Aging Brain:
Brain Energy Metabolism: Cellular Aspects and Relevance to Functional Brain Imaging, P.J. Magistretti, S. Joray, and L. Pellerin
Functional Imaging in Cognitively Intact Aged People, N.D. Anderson and C.L. Grady
Functional Brain Studies of the Neurometabolic Bases of Cognitive and Behavioral Changes in Alzheimer's Disease, P. Pietrini, M.L. Furey, M. Guazzelli, and G.E. Alexander
Biochemical Correlates of Memory Impairments:
Cholinergic Basal Forebrain Systems in the Primate Central Nervous System: Anatomy, Connectivity, Neurochemistry, Aging, Dementia, and Experimental Therapeutics, E.J. Mufson and J.H. Kordower
Glutamate Receptors in Aging and Alzheimer's Disease, A. Mishizen, M. Ikonomovic, and D.M. Armstrong
Tau Phosphorylation, L. Buée and A. Delacourte
Hereditary Basis of Alzheimer's Disease and Related Dementias:
Etiology, Genetics, and Pathogenesis of Alzheimer's Disease, C. McKeon-O'Malley and R. Tanzi
Nonhereditary Mechanisms of Alzheimer's Disease:
Inflammation, Free Radicals, Glycation, Metabolism and Apoptosis, and Heavy Metals, M.P. Mattson
Rodent Models of Age-Related Memory Impairments:
Rodent Models of Age-Related Memory Impairments, D.K. Ingram
Genetically Engineered Models of Human Age-Related Neurogenerative Diseases, J.C. Vickers
Nonhuman Primate and Other Vertebrate Models of Brain Aging:
Cognitive Aging in Nonhuman Primates, M.G. Baxter
Brain Aging in Strepsirhine Primates, E.P. Gilissen, M. Dhenain, and J.M. Allman
Age-Related Morphologic Alterations in the Brain of Old World and New World Anthropoid Monkeys, P.R. Hof and H. Duan
The Study of Brain Aging in Great Apes, J.M. Erwin, E.A. Nimchinsky, P.J. Gannon, D.P. Perl, and P.R. Hof
Neurobiological Models of Aging in the Dog and Other Vertebrate Species, E. Head, N.W. Milgram, and C.W. Cotman
Interventions:
Estrogens and Alzheimer's Disease, N.D. Tsopelas and D.B. Marin
Cholinergic Treatments of Alzheimer's Disease, N.D. Tsopelas and D.B. Marin
Anti-Inflammatory and Antioxidant Therapies in Alzheimer's Disease, P.S. Aisen and G.M. Pasinetti
Senses: Sensory Cortices and Primary Afferent Functions:
Vision:
The Retina in Aging and in Alzheimer's Disease, R.O. Kuljis
Pathogenesis of Glaucomatous Optic Neuropathy, M.R. Hernandez and A.H. Neufeld
Color Vision, Object Recognition, and Spatial Localization in Aging and Alzheimer's Disease, A. Cronin-Golomb
Hearing:
Anatomical and Neurochemical Bases of Presbycusis, R.D. Frisina, Jr
Age, Noise, and Ototoxic Agents, R.J. Salvi, D. Ding, A.C. Eddins, S.L. McFadden, and D. Henderson
Auditory Temporal Processing during Aging, D.R. Frisinia, R.D. Frisinia, Jr., K.B. Snell, R. Burkard, J.P. Walton, and J.R. Ison
Neurophysiological Manifestations of Aging in the Peripheral and Central Auditory Nervous System, J.P. Walton and R. Burkard
Genetics and Age-Related Hearing Loss, S.L. McFadden
Animal Models of Presbycusis and the Aging Auditory System, J.F. Willott
The Development of Animal Models for the Study of Presbycusis: Building a Behavioral Link between Perception and Physiology, J.R. Ison
Rehabilitation for Presbycusis, D.G. Sims and R. Burkard
Chemical Senses:
Olfaction and Gustation in Normal Aging and Alzheimer's Disease, R.L. Doty
Locomotion: Basal Ganglia and Muscular Functions:
Functional Impairments in Humans:
Aging Effects on Muscle Properties and Human Performance, S.A. Jubrias and K.E. Conley
Parkinson's Disease: Symptoms and Age Dependency, S.A. Eshuis and K.L. Leenders
Pathology and Biochemistry of Aging and Disease of Basal Ganglia:
The Basal Ganglia Dopaminergic Systems in Normal Aging and Parkinson's Disease, J.N. Joyce
Huntington's Disease, S.E. Browne and M.F. Beal
Animal Models:
Biochemical and Anatomical Changes in Basal Ganglia of Aging Animals, J.A. Stanford, M.A. Hebert, and G.A. Gerhardt
Homeostasis: Hypothalamus and Related Systems:
Reproduction and the Aging Brain:
Male Sexual Behavior during Aging, H. Kuno, M. Godschalk, and T. Mulligan
Sexual Behavior in Aging Women, N.E. Avis
Factors Influencing the Onset of Female Reproductive Senescence, P.S. LaPolt and J.K.H. Lu
Female Sexuality during Aging, N.L. McCoy
Hypothalamic Neuropeptide Gene Expression in Postmenopausal Women, N.E. Rance and T.W. Abel
Neuroendocrine Aspects of Female Reproductive Aging, P.M. Wise and M.J. Smith
Hypothalamic Changes Relevant to Reproduction in Aging Male Rodents, D.A. Gruenewald and A.M. Matsumoto
Metabolism and the Aging Brain:
Regulation of Energy Intake in Old Age, S.B. Roberts and N.P. Hays
Thermoregulation during Aging, B.A. Horwitz, A.M. Gabaldón, and R.B. McDonald
Biological Rhythms and the Aging Brain:
Sleep and Hormonal Rhythms in Humans, G. Copinschi, R. Leproult, and E. Van Cauter
Circadian Rhythms and Sleep in Aging Rodents, D.E. Kolker and F.W. Turek
Glucocorticoid Secretion and the Aging Brain:
Clucocorticoids and the Aging Brain: Cause or Consequence?
P.J. Lucassen and E.R. De Kloet
Growth Hormone, Insulin-like Growth Factor-1, and the Aging Brain, P.L. Thornton and W.E. Sonntag
Automatic Nervous System and the Aging Brain:
The Aged Sympathetic Nervous System, G.A. Kuchel and T. Cowen
Appendix
Basic Genetic Concepts