Protein Degradation in Health and Disease
Protein degradation has been identified as a centerpiece of regulation of cell functions. Not surprisingly, its deregulation is implied in almost any pathological condition. This book describes how aged proteins are eliminated during cell metabolism, how cell proliferation is regulated by protein degradation and how its deregulation can contribute to the development of cancer, how protein degradation is modified during normal and abnormal aging, in particular with regard to Alzheimer's disease and other degenerative diseases of the brain and central nervous system. Attempts aiming at correcting these pathologies by interfering with deviations of the normal pathway of protein degradation are also treated
eBook, English, 2002
Springer Berlin Heidelberg : Imprint : Springer, Berlin, Heidelberg, 2002
1 online resource (x, 130 pages 12 illustrations)
9783642563737, 9783642627149, 9783540425946, 3642563732, 3642627145, 3540425942
840292196
Printed edition:
Roles of SCF and VHL Ubiquitin Ligases in Regulation of Cell Growth
Aging of Proteins and the Proteasome
Pathways of Protein Degradation and How They Are Affected by Age
Protein Degradation in Alzheimer's Disease and Aging of the Brain
Protein Degradation in Human Disease
The 26S Proteasome
Proteasome Inhibitors