Proteases as targets for therapy
This volume is the first to combine latest information on viral, microbial and cellular proteolytic enzymes as potential targets for human therapeutics. Proteases control a large array of physiological reactions, and are involved in a variety of pathological processes for which effective medications are currently needed and/or being sought after. Although protease inhibitors have been investigated for many years, few have been employed therapeutically. Recent break- through by HIV protease inhibitors as therapeutic drugs has re-encouraged the search for inhibitors of other proteolytic enzymes. Klaus von der Helm, who described the first viral protease has brought leading experts together to discuss not only the success and problems of clinical use and continuing prospects, but to review further potential drug targets. This volume provides detailed information and evaluations of key viral, bacterial, fungal, and cellular proteases as potential future drug candidates
1 online resource (xxviii, 410 pages) : illustrations (some color)
9783642570926, 9783642630231, 9783540661184, 3642570925, 3642630235, 3540661182
828735738
Print version:
Section I. Human Immunodeficiency Virus Protease Inhibitors
1 The Road to Fortovase. A History of Saquinavir, the First Human Immunodeficiency Virus Protease Inhibitor
2 Clinical Experience with Human Immunodeficiency Virus Protease Inhibitors: Antiretroviral Results, Questions and Future Strategies
3 The Nature of Resistance to Human Immunodeficiency Virus Type-1 Protease Inhibitors
4 The Next Generation of Human Immunodeficiency Virus Protease Inhibitors: Targeting Viral Resistance
Section II. Other Viral (Non-HIV) Protease Inhibitors
5 The Proteinases Encoded by Hepatitis C Virus as Therapeutic Targets
6 The Human Herpes-Virus Proteases
7 The 3C Proteinases of Picornaviruses and Other Positive-Sense, Single-Stranded RNA Viruses
8 Adenovirus Proteinase-Antiviral Target for Triple-Combination Therapy on a Single Enzyme: Potential Inhibitor-Binding Sites
9 Proteinases as Virulence Factors in Bacterial Diseases and as Potential Targets for Therapeutic Intervention with Proteinase Inhibitors
10 Parasite Proteases as Targets for Therapy
Section III. (Non-Viral) Proteases Involved in Diseases
11 Host Proteinases as Targets for Therapeutic Intervention
12 The Role of Metalloprotease Inhibitors in Cancer and Chronic Inflammatory Diseases
13 The Tumor Necrosis Factor-? Converting Enzyme
14 Serine Elastases in Inflammatory and Vascular Diseases
15 Inhibitors of Thrombin and Factor Xa
16 Inhibitors of Papain-Like Cysteine Peptidases in Cancer
17 Caspases and Their Natural Inhibitors as Therapeutic Targets for Regulating Apoptosis
18 Proteasome and Apoptosis
19 Proteolytic Processing of the Amyloid Precursor Protein of Alzheimer's Disease
20 Presenilins and?-Amyloid Precursor Protein-Proteolytically Processed Proteins Involved in the Generation of Alzheimer's Amyloid? Peptide
Softcover reprint of the hardcover 1st edition 2000